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Titolo:
Maternal antibody passively transferred interferes with rabies vaccinationin hamsters
Autore:
Bernardi, F; Ito, FH;
Indirizzi:
Univ Sao Paulo, Coll Vet Med & Zootechny, Dept Prevent Vet Med & Anim Hlth, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Vet Med & Anim Hlth, Sao Paulo, Brazil
Titolo Testata:
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
fascicolo: 3, volume: 23, anno: 2000,
pagine: 185 - 195
SICI:
0147-9571(200007)23:3<185:MAPTIW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Keywords:
maternal antibodies; passive immunization; vaccination; rabies; hamsters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Bernardi, F Univ Sao Paulo, Coll Vet Med & Zootechny, Dept Prevent Vet Med& Anim Hlth, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil nim Hlth, Sao Paulo, Brazil
Citazione:
F. Bernardi e F.H. Ito, "Maternal antibody passively transferred interferes with rabies vaccinationin hamsters", COMPAR IMM, 23(3), 2000, pp. 185-195

Abstract

Transference and interference of maternal immunity to offspring after rabies vaccination were studied in hamsters. Females were vaccinated or not before mating and offspring were vaccinated at the age of 7, 14, 21 and 30 days. Other pups were maintained as controls. Thirty days after vaccination pups were challenged intracerebrally with CVS virus. Mouse neutralization tests were used to verify antibody titers. Mortality of 97.0, 76.9, 60.9 and 24.0% was observed in pups vaccinated at 7, 14, 21 and 30 days respectively,born from vaccinated dams, while in pups from non-vaccinated dams, mortality was 51.4, 28.6, 8.7 and 0.0%. Statistically significant associations were found between mortality and age at vaccination, by simple linear regression with y = -3.1169x + 120.8 (p = 0.008; r(2) = 0.98) for litters vaccinated and born from vaccinated dams and y = -2.2541x + 62.7495 (p = 0.03: r(2) = 0.93) for pups vaccinated and born from non-vaccinated dams. Immunological response to vaccination in pups born from vaccinated mothers was delayed 11 days, when compared to that observed in pups of non-vaccinated mothers. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 08:46:10