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Titolo:
Circumventricular organs: Definition and role in the regulation of endocrine and autonomic function
Autore:
Ganong, WF;
Indirizzi:
Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 5-6, volume: 27, anno: 2000,
pagine: 422 - 427
SICI:
0305-1870(200005/06)27:5-6<422:CODARI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GROWTH-HORMONE; ANGIOTENSIN-II; BRAIN; HYPOTHALAMUS; BIOSYNTHESIS; ALDOSTERONE; BINDING;
Keywords:
area postrema; blood-brain barrier; circumventricular organs; median eminence; neuroendocrine control; neurohypophysis; organum vasculosum lamina terminalis; subfornical organ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ganong, WF Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143USA Univ Calif San Francisco San Francisco CA USA 94143 94143 USA
Citazione:
W.F. Ganong, "Circumventricular organs: Definition and role in the regulation of endocrine and autonomic function", CLIN EXP PH, 27(5-6), 2000, pp. 422-427

Abstract

1. The circumventricular organs (CVO) are structures that permit polypeptide hypothalamic hormones to leave the brain without disrupting the blood-brain barrier (BBB) and permit substances that do not cross the BBB to trigger changes in brain function.2. In mammals, CVO include only the median eminence and adjacent neurohypophysis, organum vasculosum lamina terminalis, subfornical organ and the area postrema.3. The CVO are characterized by their small size, high permeability and fenestrated capillaries. The subcommissural organ is not highly permeable anddoes not have fenestrated capillaries, but new evidence indicates that it may be involved in the hypertension produced by aldosterone acting on the brain.4. Feedback control of corticotropin-releasing hormone (CRH) secretion is exerted by free steroids diffusing into the brain, but substances such as cytokines and angiotensin II act on CVO to produce increases in CRH secretion, Gonadal steroids also diffuse into the brain to regulate gonadotrophin-releasing hormone secretion, Thyrotropin-releasing hormone secretion is regulated by thyroid hormones transported across cerebral capillaries. However,CVO may be involved in the negative feedback control of growth hormone andprolactin secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:25:04