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Titolo:
Effects of experimental obstructive jaundice on contractile responses of dog isolated blood vessels: Role of endothelium and duration of bile duct ligation
Autore:
Utkan, ZN; Utkan, T; Sarioglu, Y; Gonullu, NN;
Indirizzi:
Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Derince, Kocaeli, Turkey Kocaeli Univ Derince Kocaeli Turkey TR-41900 900 Derince, Kocaeli, Turkey Kocaeli Univ, Fac Med, Dept Gen Surg, TR-41900 Derince, Kocaeli, Turkey Kocaeli Univ Derince Kocaeli Turkey TR-41900 900 Derince, Kocaeli, Turkey Cumhuriyet Univ, Fac Med, Dept Pharmacol, Sivas, Turkey Cumhuriyet Univ Sivas Turkey iv, Fac Med, Dept Pharmacol, Sivas, Turkey
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 5-6, volume: 27, anno: 2000,
pagine: 339 - 344
SICI:
0305-1870(200005/06)27:5-6<339:EOEOJO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; NITRIC-OXIDE; RELAXING FACTOR; RATS; REACTIVITY; HYPOTENSION; CHOLESTASIS; CIRCULATION; KIDNEY;
Keywords:
dog; 5-hydroxytryptamine; nitric oxide; noradrenaline; obstructive jaundice; vascular smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Utkan, T Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Derince, Kocaeli,Turkey Kocaeli Univ Derince Kocaeli Turkey TR-41900 ce, Kocaeli, Turkey
Citazione:
Z.N. Utkan et al., "Effects of experimental obstructive jaundice on contractile responses of dog isolated blood vessels: Role of endothelium and duration of bile duct ligation", CLIN EXP PH, 27(5-6), 2000, pp. 339-344

Abstract

1. We examined the effects of experimental obstructive jaundice caused by bile duct ligation (BDL) on vascular smooth muscle function, as well as theunderlying mechanisms involved, by recording responses to noradrenaline (NA), 5-hydroxy-tryptaminc (5-HT) and acetylcholine (ACh) in canine isolated renal arteries and to NA in Isolated mesenteric arteries in vitro. All studies were performed 7 days after the onset of BDL in renal arteries and 3, 7and 15 days after the onset of BDL in mesenteric arteries.2. The maximum contraction evoked by both NA and 5-HT was significantly attenuated with no change in agonist potency (pD(2) value) in renal arteries with endothelium obtained from 7 day BDL dogs when compared with those fromsham-operated controls (SO). However, the reduction almost disappeared when the endothelium was removed. In contrast, no change in the responsivenessof renal arteries to KCI could be detected at 7 day BDL. Endothelium-dependent relaxations produced by ACh were significantly increased in renal artery rings from 7 day BDL dogs, but the endothelium-independent relaxations produced by papaverine in BDL preparations were not changed when compared with SO controls.3. At 7 and 15 days after BDL, the E-max values of the mesenteric ring of BDL dogs to NA were significantly lower than that of SO controls, whereas 3days after surgery there was no significant difference. The pD(2) values in arteries obtained from 15 day BDL, animals were significantly Lower than those obtained from SO control animals. However, no significant changes in pot values were seen 3 and 7 days after the onset of BDL.4. In conclusion, it is suggested that enhanced production and/or release of nitric oxide, mainly of endothelial origin, is associated with reduced vascular responses to contractile agents in experimental obstructive jaundice and that this effect is related to the duration of obstructive jaundice. These results may explain, at least in part, a cause of hypotension that leads to renal failure in patients with obstructive jaundice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:50:57