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Titolo:
The inherited susceptibility to cancer
Autore:
Guilford, P;
Indirizzi:
Univ Otago, Dept Biochem, Canc Genet Lab, Dunedin, New Zealand Univ OtagoDunedin New Zealand em, Canc Genet Lab, Dunedin, New Zealand
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 4, volume: 57, anno: 2000,
pagine: 589 - 603
SICI:
1420-682X(200004)57:4<589:TISTC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIJMEGEN BREAKAGE SYNDROME; TUMOR-SUPPRESSOR PROTEIN; PEUTZ-JEGHERS-SYNDROME; CELL-CYCLE CHECKPOINT; RECEPTOR TYROSINE KINASE; HEPATOCYTE GROWTH-FACTOR; FAMILIAL GASTRIC-CANCER; NONPOLYPOSIS COLORECTAL-CANCER; NEUROFIBROMATOSIS TYPE-1 GENE; CHRONIC LYMPHOCYTIC-LEUKEMIA;
Keywords:
cancer; familial; inherited; predisposition; susceptibility; gene;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
188
Recensione:
Indirizzi per estratti:
Indirizzo: Guilford, P Univ Otago, Dept Biochem, Canc Genet Lab, POB 56, Dunedin, NewZealand Univ Otago POB 56 Dunedin New Zealand , Dunedin, New Zealand
Citazione:
P. Guilford, "The inherited susceptibility to cancer", CELL MOL L, 57(4), 2000, pp. 589-603

Abstract

The study of inherited cancer syndromes has led to the identification of over 25 genes directly involved in tumorigenesis. These genes have functionsas diverse as signal transduction, cell cycle control, cell-to-cell adhesion, control of apoptosis, DNA repair and the maintenance of genome stability. Most cancer syndromes have a dominant pattern of inheritance, due to germline loss-of-function mutation of a tumour suppressor gene. All the recessively inherited genes have been implicated in the maintenance of genome stability. This review summarises our current understanding of the functions of the major cancer susceptibility genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:53:38