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Titolo:
Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. Implications for depression
Autore:
Kaminska, M; Harris, J; Gijsbers, K; Dubrovsky, B;
Indirizzi:
McGill Univ, Sch Med, Neurophysiol Lab, Montreal, PQ H3G 1X9, Canada McGill Univ Montreal PQ Canada H3G 1X9 Lab, Montreal, PQ H3G 1X9, Canada Univ Stirling, Dept Psychol, Stirling FK9 4LA, Scotland Univ Stirling Stirling Scotland FK9 4LA chol, Stirling FK9 4LA, Scotland
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 3, volume: 52, anno: 2000,
pagine: 229 - 234
SICI:
0361-9230(200006)52:3<229:DS(CDE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; HIPPOCAMPAL PRIMED BURST; URETHANE-ANESTHETIZED RATS; CENTRAL-NERVOUS-SYSTEM; GABA-A RECEPTOR; CUSHINGS-SYNDROME; PSYCHIATRIC MANIFESTATIONS; MEMORY PERFORMANCE; ADRENAL-STEROIDS; MAJOR DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Dubrovsky, B McGill Univ, Sch Med, Neurophysiol Lab, 3445 Drummond St,701,Montreal, PQH3G 1X9, Canada McGill Univ 3445 Drummond St,701 Montreal PQ Canada H3G 1X9 a
Citazione:
M. Kaminska et al., "Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. Implications for depression", BRAIN RES B, 52(3), 2000, pp. 229-234

Abstract

It is well-established that levels of corticosterone sufficient to occupy Type II glucocorticoid receptors produce a decrement in long-term potentiation (LTP) in the dentate gyrus of the hippocampus in rats. In the present series of experiments we investigate the interaction of corticosterone and the neurosteroid dehydroepiandrosterone sulfate (DHEAS) on LTP in the rat dentate gyrus. In confirmation of previous studies, we found that corticosterone (2 mg/kg) had decremental effects on LTP. However, simultaneous injection of corticosterone and DHEAS (30 mg/kg) elicited excitatory post-synapticpotentials and population spikes that were not significantly different from those observed in control animals. The results are discussed in terms of the interaction of the two hormones, the agonist effects of DHEAS on sigma receptors, and their relation with the antidepressant effects of DHEA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:54:51