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Titolo:
Serotonergic and kynurenic pathways in rats exposed to foot shock
Autore:
Pawlak, D; Takada, Y; Urano, T; Takada, A;
Indirizzi:
Med Acad Bialystok, Dept Pharmacodynam, PL-15230 Bialystok, Poland Med Acad Bialystok Bialystok Poland PL-15230 PL-15230 Bialystok, Poland Hamamatsu Univ, Sch Med, Dept Pathophysiol, Hamamatsu, Shizuoka 43131, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 43131 atsu, Shizuoka 43131, Japan Hamamatsu Univ, Sch Med, Dept Physiol, Hamamatsu, Shizuoka 43131, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 43131 atsu, Shizuoka 43131, Japan
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 3, volume: 52, anno: 2000,
pagine: 197 - 205
SICI:
0361-9230(200006)52:3<197:SAKPIR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL CELL-DEATH; BRAIN-SEROTONIN; 5-HYDROXYINDOLEACETIC ACID; AMINOTRANSFERASE-I; CHRONIC STRESS; AMINO-ACIDS; TRYPTOPHAN; RESPONSES; 3-HYDROXYKYNURENINE; NORADRENALINE;
Keywords:
serotonin; kynurenine; 3-hydroxykynurenine; kynurenic acid; foot shock;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Pawlak, D Med Acad Bialystok, Dept Pharmacodynam, Mickiewicza 2C, PL-15230Bialystok, Poland Med Acad Bialystok Mickiewicza 2C Bialystok Poland PL-15230 and
Citazione:
D. Pawlak et al., "Serotonergic and kynurenic pathways in rats exposed to foot shock", BRAIN RES B, 52(3), 2000, pp. 197-205

Abstract

Electric foot shock was applied to rats and levels of tryptophan and its metabolites were measured in the plasma, central nervous system and peripheral tissues. Metabolites of tryptophan are the results of the enhancement ofserotonergic and kynurenine pathways. Plasma levels of tryptophan increased significantly immediately after the foot shock and returned to normal values within 24 h. Tryptophan levels also increased in all the brain areas immediately after stress application and returned to normal values within 24 h. Foot shock elevated the levels of kynurenine in the plasma, liver, kidney and every parts of the brain. 3-Hydroxykynurenine and kynurenic acid levers were increased in the brain. The present observations suggest that stress activates not only serotonergic pathway but also kynurenine pathway in the central nervous system and periphery. Some metabolites of kynurenine pathway, such as 3-hydroxykynurenine, are neurotoxic while other metabolite, such as kynurenic acid, may be neuroprotective. Increase in serotonin level in the hypothalamus and midbrain stabilises emotion and prevents mood disorders. Therefore, some brain dysfunction resulting from stress may be prevented by the metabolites of tryptophan. The balance of these functions may be important in the maintenance of nerve integrity under stress conditions. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:20:55