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Titolo:
Immunohistochemical estimation of brain choline acetyltransferase and somatostatin related to the impairment of avoidance learning induced by thiamine deficiency
Autore:
Nakagawasai, O; Tadano, T; Hozumi, S; Tan-No, K; Niijima, F; Kisara, K;
Indirizzi:
Tohoku Pharmaceut Univ, Dept Pharmacol, Aoba Ku, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ Sendai Miyagi Japan 9818558 Miyagi 9818558, Japan
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 3, volume: 52, anno: 2000,
pagine: 189 - 196
SICI:
0361-9230(200006)52:3<189:IEOBCA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRITHIAMINE-INDUCED LESIONS; NEUROPEPTIDE-Y LEVELS; RAT-BRAIN; CEREBRAL-CORTEX; IBOTENIC ACID; SUBSTANCE-P; HIPPOCAMPUS; FOREBRAIN; GLUTAMATE; NEURONS;
Keywords:
choline acetyltransferase; somatostatin; thiamine deficiency; impairment of avoidance learning; immunohistochemical estimation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagawasai, O Tohoku Pharmaceut Univ, Dept Pharmacol, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ 4-4-1 Komatsushima Sendai Miyagi Japan 9818558
Citazione:
O. Nakagawasai et al., "Immunohistochemical estimation of brain choline acetyltransferase and somatostatin related to the impairment of avoidance learning induced by thiamine deficiency", BRAIN RES B, 52(3), 2000, pp. 189-196

Abstract

We have found that thiamine-deficient (TD) rats show significant impairment of avoidance learning on the 25th day after the start of TD diet, as measured by passive- avoidance task. Administration of physostigmine (0.1 mg/kg, i.p.) from the 14th day after the start of TD diet improved the impairment of avoidance learning to the pair-fed (PF) control level by the 25th day. However, the recovery effect of physostigmine did not occur on the 25th day when the treatment was begun on the 21st day. To ascertain the correlation between the cholinergic neuronal function in rat brain and the avoidance learning impairment induced by TD, the immunohistochemical distribution of brain choline acetyltransferase (ChAT) was determined by fluorescence intensity using two-dimensional microphotometry. The intensity of the ChAT fluorescence started to decrease in the cortex and hippocampus on the 14th day and showed a marked decrease in the cortex, hippocampus and thalamus on the 25th day of TD feeding in comparison with PF controls. The intensity of thesomatostatin (SST) fluorescence was unchanged on the 14th day of TD feeding, but on the 25th day, SST was significantly decreased in comparison with PF controls. Furthermore, physostigmine treatment from 14th day after the start of TD diet reversed SST fluorescence intensity to the control level bythe 25th day. These results suggest that the impairment of avoidance learning induced by TD may involve not only cholinergic but also somatostatinergic systems. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:59:27