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Titolo:
Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 andcorticotrophin releasing factor inhibit feeding via agouti-related proteinindependent pathways in the rat
Autore:
Edwards, CMB; Abbott, CR; Sunter, D; Kim, MS; Dakin, CL; Murphy, KG; Abusnana, S; Taheri, S; Rossi, M; Bloom, SR;
Indirizzi:
Hammersmith Hosp, ICSM, Endocrine Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN ne Unit, London W12 0NN, England
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 866, anno: 2000,
pagine: 128 - 134
SICI:
0006-8993(20000602)866:1-2<128:CAATGP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; LEPTIN RECEPTOR; FOOD-INTAKE; MELANOCORTIN RECEPTORS; FRAMESHIFT MUTATION; HYPOTHALAMIC CART; OBESITY SYNDROME; BODY-WEIGHT; IN-VIVO; MICE;
Keywords:
melanocortin; anorectic; leptin; intracerebroventricular; food intake;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bloom, SR Hammersmith Hosp, ICSM, Endocrine Unit, London W12 0NN, England Hammersmith Hosp London England W12 0NN ondon W12 0NN, England
Citazione:
C.M.B. Edwards et al., "Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 andcorticotrophin releasing factor inhibit feeding via agouti-related proteinindependent pathways in the rat", BRAIN RES, 866(1-2), 2000, pp. 128-134

Abstract

The melanocortin-4 receptor (MC4-R) appears to be an important downstream mediator of the action of leptin. We examined to what extent the anorectic effects of cocaine- and amphetamine-regulated transcript (CART), glucagon-like peptide-1 (GLP-1) and corticotrophin releasing factor (CRF) might be mediated via MC4-R. alpha-Melanocyte stimulating hormone (alpha-MSH), the MC4-R agonist, administered intracerebroventricularly (ICV) at a dose of 1 nmol reduced food intake by approximately half. Agouti-related protein (Agrp) (83-132), a biologically active fragment of the endogenous MC4-R antagonist, administered ICV at a dose of 1 nmol completely blocked the anorectic effect of 1 nmol alpha-MSH. CART (55-102) (0.2 nmol), GLP-1 (3 nmol) and CRF (0.3 nmol) produced a reduction in feeding of approximately the same magnitude as 1 nmol alpha-MSH. Agrp (83-132) (1 nmol) administered ICV did not block the anorectic effects of CART (55-102) (1 h food intake, 0.2 nmol CART (55-102), 2.7+/-0.8 g vs. CART (55-102)+Agrp (83-132), 2.6+/-0.6 g, P=0.87; saline control 5.4+/-0.3 g, P<0.001 vs. both groups). Agrp (83-132) also did not block the anorectic effects of GLP-1 or CRF (1 h food intake, 0.3 nmol CRF, 0.7+/-0.3 g vs. CRF+Agrp (83-132), 0.7+/-0.3 g, P=0.91; 3 nmol GLP-1, 1.9+/-0.4 g vs. GLP-1+Agrp (83-132), 1.1+/-0.5 g, P=0.23; saline control 5.0+/-0.6 g, P<0.001 vs. all four groups). Thus, as previous data suggests,GLP-1 and CRF do not appear to reduce food intake predominantly via MC4-R,we here demonstrate for the first time that CART, in addition to GLP-1 andCRF primarily acts via Agrp independent pathways. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:58:28