Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Blood viscosity, plasma adrenaline and pasting insulin in hypertensive patients with left ventricular hypertrophy - ICARUS, a LIFE substudy
Autore:
Hoieggen, A; Fossum, E; Nesbitt, SD; Palmieri, V; Kjeldsen, SE;
Indirizzi:
Univ Oslo, Ulleval Hosp, Dept Internal Med, NO-0407 Oslo, Norway Univ Oslo Oslo Norway NO-0407 p, Dept Internal Med, NO-0407 Oslo, Norway Univ Michigan Hosp, Dept Internal Med, Div Hypertens, Ann Arbor, MI 48109 USA Univ Michigan Hosp Ann Arbor MI USA 48109 ertens, Ann Arbor, MI 48109 USA Cornell Univ, Weill Med Coll, New York Hosp, Div Cardiol, New York, NY USACornell Univ New York NY USA ew York Hosp, Div Cardiol, New York, NY USA
Titolo Testata:
BLOOD PRESSURE
fascicolo: 2-3, volume: 9, anno: 2000,
pagine: 83 - 90
SICI:
0803-7051(2000)9:2-3<83:BVPAAP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNTREATED ESSENTIAL-HYPERTENSION; CARDIOVASCULAR EVENTS; RESISTANCE; PRESSURE; MEN; SENSITIVITY; EPINEPHRINE; HEMATOCRIT; HEMOGLOBIN; HEALTHY;
Keywords:
hypertension; insulin resistance; plasma adrenaline; sympathetic nervous system activity; whole blood viscosity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hoieggen, A Univ Oslo, Ulleval Hosp, Dept Internal Med, NO-0407 Oslo, Norway Univ Oslo Oslo Norway NO-0407 rnal Med, NO-0407 Oslo, Norway
Citazione:
A. Hoieggen et al., "Blood viscosity, plasma adrenaline and pasting insulin in hypertensive patients with left ventricular hypertrophy - ICARUS, a LIFE substudy", BLOOD PRESS, 9(2-3), 2000, pp. 83-90

Abstract

We have seen relationships between whole blood viscosity (WBV) and components of the metabolic cardiovascular syndrome in borderline hypertensive young men and suggested that sympathetic nervous system (SNS) activity may be a mediator. In the present study we aimed to test this hypothesis in established hypertension and to investigate the relationship between WBV and cardiac dimensions. Unmedicated patients (n = 42) with stage II-III hypertension and electrocardiographic left ventricular hypertrophy (LVH) underwent hyperinsulinemic isoglycemic glucose clamp to assess glucose disposal rate (GDR) and echocardiographic studies. WBV, plasma catecholamines and insulin were measured in arterialized venous blood. WBV at high shear rate correlatedwith baseline plasma adrenaline (r = 0.33, p = 0.04) and fasting insulin (r = 0.34, p = 0.04) while there was a negative trend for GDR (r = -0.21, p = 0.2). WBV at low shear rate correlated with plasma adrenaline (r = 0.49, p = 0.002) and resting heart rate (r = 0.36, p = 0.02). WBV was higher in smokers than in non-smokers (p = 0.02) and in males than in females (p = 0.02). Fasting insulin independently explained 12% of the variation in WBV at high shear, while baseline adrenaline independently explained 17% of the variation in WBV at low shear. Systolic blood pressure explained 31% of the variation in LV mass index. Thus, we demonstrate positive relationships between blood viscosity versus plasma adrenaline and fasting insulin in hypertensive patients with LVH. We suggest that adrenergic activity may increase hematocrit and viscosity and hence reduce insulin sensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:37:26