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Titolo:
Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation
Autore:
Almeida-Porada, G; Porada, CD; Tran, N; Zanjani, ED;
Indirizzi:
Univ Nevada, Dept Vet Affairs Med Ctr, Reno, NV 89557 USA Univ Nevada Reno NV USA 89557 ept Vet Affairs Med Ctr, Reno, NV 89557 USA
Titolo Testata:
BLOOD
fascicolo: 11, volume: 95, anno: 2000,
pagine: 3620 - 3627
SICI:
0006-4971(20000601)95:11<3620:COHSCP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; IN-UTERO TRANSPLANTATION; NONHEMATOPOIETIC TISSUES; OSTEOGENESIS IMPERFECTA; ENGRAFTMENT; MICE; LIVER; EXPRESSION; CHIMERAS; MICROENVIRONMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Almeida-Porada, G VA Med Ctr, 151B,1000 Locust St, Reno, NV 89520 USA VA Med Ctr 151B,1000 Locust St Reno NV USA 89520 520 USA
Citazione:
G. Almeida-Porada et al., "Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation", BLOOD, 95(11), 2000, pp. 3620-3627

Abstract

Both in utero and postnatal hematopoietic stem cell (HSC) transplantation would benefit from the development of approaches that produce increased levels of engraftment or a reduction in the period of time required for reconstitution. We used the in utero model of human-sheep HSC transplantation to investigate ways of improving engraftment and differentiation of donor cells after transplantation. We hypothesized that providing a more suitable microenvironment in the form of human stromal cell progenitors simultaneously with the transplanted hu-man HSC would result in higher rates of engraftment or differentiation of the human cells in this xenogeneic model. The results presented here demonstrate that the cotransplantation of both autologousand allogeneic human bone marrow-derived stromal cell progenitors resultedin an enhancement of long-term engraftment of human cells in the bone marrow of the chimeric animals and in earlier and higher levels of donor cells in circulation both during gestation and after birth. By using marked stromal cells, we have also demonstrated that injected stromal cells alone engraft and remain functional within the sheep hematopoietic microenvironment. Application of this method to clinical HSC transplantation could potentiallylead to Increased levels of long-term engraftment, a reduction in the timefor hematopoietic reconstitution, and a means of delivery of foreign genesto the hematopoietic system. (Blood. 2000;95: 3620-3627) (C) 2000 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:26:05