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Titolo:
Glycoprotein IIb/IIIa receptor inhibitor attenuates platelet aggregation induced by thromboxane A2 during in vitro nonpulsatile ventricular assist circulation
Autore:
Yomo, T; Serna, DL; Powell, LL; Wang, D; Wilson, SE; Ishimaru, S; Chen, JC;
Indirizzi:
Univ Calif Irvine, Irvine Med Ctr, Div Cardiothorac Surg, Orange, CA 92668USA Univ Calif Irvine Orange CA USA 92668 diothorac Surg, Orange, CA 92668USA Tokyo Med Univ Hosp, Dept Surg 2, Tokyo, Japan Tokyo Med Univ Hosp TokyoJapan ed Univ Hosp, Dept Surg 2, Tokyo, Japan
Titolo Testata:
ARTIFICIAL ORGANS
fascicolo: 5, volume: 24, anno: 2000,
pagine: 355 - 361
SICI:
0160-564X(200005)24:5<355:GIRIAP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BYPASS; CARDIOGENIC-SHOCK; A(2) FORMATION; ACTIVATION; THROMBIN; THERAPY; COMPLEX; IIIA;
Keywords:
ventricular assist device; thromboxane A2; platelet aggregation; platelet secretion; glycoprotein IIb/IIIa receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, JC Cardiothorac Surg, 3288 Moanalua Rd, Honolulu, HI 96819 USA Cardiothorac Surg 3288 Moanalua Rd Honolulu HI USA 96819 6819 USA
Citazione:
T. Yomo et al., "Glycoprotein IIb/IIIa receptor inhibitor attenuates platelet aggregation induced by thromboxane A2 during in vitro nonpulsatile ventricular assist circulation", ARTIF ORGAN, 24(5), 2000, pp. 355-361

Abstract

A recent development in antithrombotic research allows the inhibition of platelet aggregation via protection of the glycoprotein IIb/IIIa receptor onthe platelet membrane. We hypothesized that a GP IIb/IIIa receptor inhibitor would inhibit thromboxane-induced platelet aggregation during circulation in our in vitro ventricular assist device (VAD) circuit and preserve long-term platelet function. Twenty-one in vitro nonpulsatile centrifugal VAD circuits were simulated for 4 days using 450 ml of fresh human whole blood with or without glycoprotein IIb/IIIa receptor inhibitor (tirofiban). Platelet aggregation and degranulation were measured in whole blood induced by ristocetin, collagen, ADP, and thromboxane A2 (TXA2). The tirofiban-treated group preserved the platelet count and tended to exert these beneficial effects by inhibiting pathologic platelet aggregation induced by TXA2, collagen, and ADP as well as degranulation. Tirofiban may be useful in preserving platelet number and function during clinical VAD use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:47:58