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Titolo:
Ripple phases induced by alpha-tocopherol in saturated diacylphosphatidylcholines
Autore:
Wang, XY; Semmler, K; Richter, W; Quinn, PJ;
Indirizzi:
Univ London Kings Coll, Div Life Sci, London SE1 8WA, England Univ London Kings Coll London England SE1 8WA i, London SE1 8WA, England Univ Jena, Inst Ultrastruct Res, D-07743 Jena, Germany Univ Jena Jena Germany D-07743 st Ultrastruct Res, D-07743 Jena, Germany
Titolo Testata:
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
fascicolo: 2, volume: 377, anno: 2000,
pagine: 304 - 314
SICI:
0003-9861(20000515)377:2<304:RPIBAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNCHROTRON X-RAY; VITAMIN-E; PHOSPHATIDYLCHOLINE LIPOSOMES; PHOSPHOLIPID-BILAYERS; MEMBRANES; MODEL; DIPALMITOYLPHOSPHATIDYLCHOLINE; UNSATURATION; TEMPERATURE; CHOLESTEROL;
Keywords:
alpha-tocopherol; phospholipids; X-ray diffraction; vitamin E; ripple phase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Quinn, PJ Univ London Kings Coll, Div Life Sci, 150 Stamford St, London SE1 8WA, England Univ London Kings Coll 150 Stamford St London England SE1 8WA d
Citazione:
X.Y. Wang et al., "Ripple phases induced by alpha-tocopherol in saturated diacylphosphatidylcholines", ARCH BIOCH, 377(2), 2000, pp. 304-314

Abstract

The effect of alpha-tocopherol on the structure and phase behavior of dilauroyl-, dimyristoyl-, dipalmitoyl-, and distearoyl-phosphatidylcholines wasexamined using X-ray diffraction and freeze-fracture electron microscopic methods. A ripple phase was observed in all of the mixtures at temperatureswell below the pretransition temperature of the corresponding pure phospholipid, Freeze-fracture studies indicated that with proportion of alpha-tocopherol less than 5 mol% a ripple phase with large periodicity (50-150 nm) predominated and with about 10 mol% alpha-tocopherol a ripple phase of periodicity about 16 nm was formed. With more than 10 mol% alpha-tocopherol planar bilayers tended to be formed. Partial phase diagrams of mixed aqueous dispersions of saturated phosphatidylcholines and alpha-tocopherol over temperature ranges about the gel to liquid-crystal phase boundary have been constructed. alpha-Tocopherol-enriched domains form ripple phases that coexist with regions of lamellar gel phase of the pure phospholipid in mixtures containing less than 10 mol% alpha-tocopherol. The presence of increasing amounts of alpha-tocopherol in the phospholipid causes an increase in the proportion of ripple phase at the expense of pure phospholipid bilayer indicating that the alpha-tocopherol-enriched domains might possess a defined stoichiometry of the two constituents. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:16:16