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Titolo:
Synthesis and analgesic activity of some side-chain modified anpirtoline derivatives
Autore:
Radl, S; Herzky, P; Proska, J; Hejnova, L; Krejci, I;
Indirizzi:
Res Inst Pharm & Biochem, CR-13060 Prague, Czech Republic Res Inst Pharm &Biochem Prague Czech Republic CR-13060 , Czech Republic
Titolo Testata:
ARCHIV DER PHARMAZIE
fascicolo: 5, volume: 333, anno: 2000,
pagine: 107 - 112
SICI:
0365-6233(200005)333:5<107:SAAAOS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONIST; 5-HT1A;
Keywords:
anpirtoline analogs; [(hetero)arylsulfanyl]methylpiperidines; [(hetero)arylsulfanyl]methylpyrrolidines; [(hetero)arylmethyl]piperazines; (hetero)aroylpiperazines; analgesic activity; 5-HT1A receptor ligands; 5-HT1B receptor ligands;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Radl, S Res Inst Pharm & Biochem, Kourimska 17, CR-13060 Prague, Czech Republic Res Inst Pharm & Biochem Kourimska 17 Prague Czech Republic CR-13060
Citazione:
S. Radl et al., "Synthesis and analgesic activity of some side-chain modified anpirtoline derivatives", ARCH PHARM, 333(5), 2000, pp. 107-112

Abstract

New derivatives of anpirtoline and deazaanpirtoline modified in the side chain have been synthesized. The series includes compounds 3 with side-chains containing piperidine or pyrrolidine rings, compounds 4 containing 8-azabicyclo[3.2.1]octane moiety, and compounds 5 having piperazine ring in theirside-chains. Their receptor binding profiles (5-HT1A, 5-HT1B) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. Optimized structures (PM3-MOPAC, Alchemy 2000, Tripes Inc.) of the synthesizedcompounds 3-5 were compared with that of anpirtoline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:43:06