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Titolo:
Regional brain atrophy in progressive supranuclear palsy and Lewy body disease
Autore:
Cordato, NJ; Halliday, GM; Harding, AJ; Hely, MA; Morris, JGL;
Indirizzi:
Prince Wales Med Res Inst, Randwick, NSW 2031, Australia Prince Wales Med Res Inst Randwick NSW Australia 2031 NSW 2031, Australia Westmead Hosp, Dept Neurol, Westmead, NSW, Australia Westmead Hosp Westmead NSW Australia pt Neurol, Westmead, NSW, Australia
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 6, volume: 47, anno: 2000,
pagine: 718 - 728
SICI:
0364-5134(200006)47:6<718:RBAIPS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PARKINSONS-DISEASE; POSITRON EMISSION TOMOGRAPHY; ALZHEIMERS-DISEASE; HUMAN AMYGDALA; HUNTINGTONS-DISEASE; OLFACTORY DYSFUNCTION; FACIAL EXPRESSIONS; DEMENTIA; BODIES; HYPOMETABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Cordato, NJ Prince Wales Med Res Inst, High St, Randwick, NSW 2031, Australia Prince Wales Med Res Inst High St Randwick NSW Australia 2031
Citazione:
N.J. Cordato et al., "Regional brain atrophy in progressive supranuclear palsy and Lewy body disease", ANN NEUROL, 47(6), 2000, pp. 718-728

Abstract

There have been no previous three-dimensional volumetric studies of regional brain atrophy in patients with pathologically confirmed progressive supranuclear palsy (PSP). Postmortem cortical and subcortical volumes were compared with neuropathology in 9 patients with PSP, 15 patients with 'Parkinson's disease, 10 patients with dementia with Lewy bodies, and 23 controls. Cases with the neuritic pathology of Alzheimer's disease were excluded. The topography of brain atrophy differed according to clinicopathological phenotype. Patients with Parkinson's disease had atrophy confined to the amygdala. Atrophy of the frontal lobe was found in both PSP and dementia with Lewybodies and correlated with increasing neurofibrillary tangle or Lewy body densities, respectively. Patients with PSP could be differentiated by theirmarked atrophy of the internal globus pallidus. Further analysis of variance revealed that trends for greater frontal lobe atrophy correlated with clinical dementia in PSP, whereas both greater frontal and hippocampal atrophy and higher densities of Lewy bodies and Lewy neurites correlated with clinical dementia in cases with Lewy bodies, The present study provides evidence for selective regional atrophy that correlates with the underlying pathology of PSP and Lewy body disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:25:16