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Titolo:
The mechanical antihyperalgesic effect of intrathecally administered MPV-2426, a novel alpha(2)-adrenoceptor agonist, in a rat model of postoperativepain
Autore:
Onttonen, T; Pertovaara, A;
Indirizzi:
Univ Helsinki, Inst Biomed, Dept Physiol, FIN-00014 Helsinki, Finland UnivHelsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland Univ Turku, Inst Biomed, Dept Physiol, SF-20500 Turku, Finland Univ TurkuTurku Finland SF-20500 Dept Physiol, SF-20500 Turku, Finland
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 6, volume: 92, anno: 2000,
pagine: 1740 - 1745
SICI:
0003-3022(200006)92:6<1740:TMAEOI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONISTS; HYPERALGESIA; CLONIDINE; DEXMEDETOMIDINE; MEDETOMIDINE; MORPHINE;
Keywords:
alpha(2)-adrenergic analgesia; clonidine; dexmedetomidine; primary hyperalgesia; radolmidine; yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Pertovaara, A Univ Helsinki, Inst Biomed, Dept Physiol, BOB 9, FIN-00014 Helsinki, Finland Univ Helsinki BOB 9 Helsinki Finland FIN-00014 nki, Finland
Citazione:
T. Onttonen e A. Pertovaara, "The mechanical antihyperalgesic effect of intrathecally administered MPV-2426, a novel alpha(2)-adrenoceptor agonist, in a rat model of postoperativepain", ANESTHESIOL, 92(6), 2000, pp. 1740-1745

Abstract

Background MPV-2426 is a novel alpha(2)-adrenoceptor agonist developed forspinal pain therapy. It has proved to be effective In physiologic and neuropathic conditions. In the current study its effectiveness on mechanical hyperalgesia was assessed in a rat model of postoperative pain. Methods: Rats with intrathecal catheters were anesthetized with pentobarbital, and a 1-cm incision was made in the plantar aspect of the foot and closed. During postoperative days 1 and 2 the antihyperalgesic effects inducedby intrathecal MPV-2426, clonidine, and dexmedetomidine were determined byassessing the hind limb withdrawal threshold to calibrated von Frey hairs applied to the skin of the hind paw adjacent to the wound. Results: MPV-2426 administered into the lumbar spinal cord produced a dose-dependent (0.3-10 mu g) attenuation of the mechanical hyperalgesia, and this antihyperalgesic effect was completely reversed by yohimbine (1 mg/kg, subcutaneous), an alpha(2)-adrenoceptor antagonist. Dexmedetomidine (1-3 mu g) produced an equipotent antihyperalgesic effect, whereas the effect of clonidine (1-10 mu g) was markedly weaker. MPV-2426 (10 mu g in 20 mu l) administered adjacent to the wound did not produce any effect. Preoperative treatment with an antihyperalgesic dose of MPV-2426 did not prevent the development of hyperalgesia,Conclusions: Intrathecal MPV-2426 dose-dependently attenuates postoperative hyperalgesia to mechanical stimulation because of an action on alpha(2) adrenoceptors. Its antihyperalgesic action Is as effective as that produced by dexmedetomidine and is considerably stronger than that produced by clonidine. However, preoperative treatment with MPV-2426 does not prevent the development of postoperative hyperalgesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:00:56