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Titolo:
Education and the risk for Alzheimer's disease: Sex makes a difference. EURODEM pooled analyses
Autore:
Letenneur, L; Launer, LJ; Andersen, K; Dewey, ME; Ott, A; Copeland, JRM; Dartigues, JF; Kragh-Sorensen, P; Baldereschi, M; Brayne, C; Lobo, A; Martinez-Lage, JM; Stijnen, T; Hofman, A;
Indirizzi:
INSERM, U330, Bordeaux, France INSERM Bordeaux FranceINSERM, U330, Bordeaux, France Erasmus Univ, Sch Med, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Odense Univ, Dept Psychiat, Odense, Denmark Odense Univ Odense DenmarkOdense Univ, Dept Psychiat, Odense, Denmark Royal Liverpool Univ Hosp, Dept Psychiat, Liverpool, Merseyside, England Royal Liverpool Univ Hosp Liverpool Merseyside England rseyside, England Natl Res Council, Targeted Program Ageing, Florence, Italy Natl Res Council Florence Italy argeted Program Ageing, Florence, Italy Univ Cambridge, Inst Publ Hlth, Cambridge, England Univ Cambridge Cambridge England ge, Inst Publ Hlth, Cambridge, England Univ Zaragoza, Dept Psychiat, Zaragoza, Spain Univ Zaragoza Zaragoza Spain v Zaragoza, Dept Psychiat, Zaragoza, Spain Univ Navarra, Dept Neurol, Pamplona, Spain Univ Navarra Pamplona SpainUniv Navarra, Dept Neurol, Pamplona, Spain
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 11, volume: 151, anno: 2000,
pagine: 1064 - 1071
SICI:
0002-9262(20000601)151:11<1064:EATRFA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENTAL STATE; DEMENTIA; PREVALENCE; AGE; OCCUPATION; ASSOCIATION; POPULATION; DIAGNOSIS; MENOPAUSE; ESTROGEN;
Keywords:
Alzheimer disease; dementia; education; sex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Letenneur, L INSERM, U330, Bordeaux, France INSERM Bordeaux FranceINSERM, U330, Bordeaux, France
Citazione:
L. Letenneur et al., "Education and the risk for Alzheimer's disease: Sex makes a difference. EURODEM pooled analyses", AM J EPIDEM, 151(11), 2000, pp. 1064-1071

Abstract

The hypothesis that a low educational level increases the risk for Alzheimer's disease remains controversial. The authors studied the association of years of schooling with the risk for incident dementia and Alzheimer's disease by using pooled data from four European population-based follow-up studies. Dementia cases were identified in a two-stage procedure that included a detailed diagnostic assessment of screen-positive subjects. Dementia and Alzheimer's disease were diagnosed by using international research criteria. Educational level was categorized by years of schooling as low (less thanor equal to 7), middle (8-11), or high greater than or equal to 12). Relative risks (95% confidence intervals) were estimated by using Poisson regression, adjusting for age, sex, study center, smoking status, and self-reported myocardial infarction and stroke. There were 493 (328) incident cases ofdementia (Alzheimer's disease) and 28,061 (27,839) person-years of follow-up. Compared with women with a high level of education, those with low and middle levels of education had 4.3 (95% confidence interval: 1.5, 11.9) and2.6 (95% confidence interval: 1.0, 7.1) times increased risks, respectively, for Alzheimer's disease. The risk estimates for men were close to 1.0. Finding an association of education with Alzheimer's disease for women only raises the possibility that unmeasured confounding explains the previously reported increased risk for Alzheimer's disease for persons with low levelsof education.

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Documento generato il 29/10/20 alle ore 21:23:46