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Titolo:
Low grade gliomas treated with adjuvant radiation therapy in the modern imaging era
Autore:
Mansur, DB; Hekmatpanah, J; Wollman, R; Macdonald, L; Nicholas, K; Beckmann, E; Mundt, AJ;
Indirizzi:
Univ Chicago Hosp, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA Univ Chicago Hosp Chicago IL USA 60637 lular Oncol, Chicago, IL 60637 USA Univ Chicago Hosp, Dept Neurosurg, Chicago, IL 60637 USA Univ Chicago Hosp Chicago IL USA 60637 t Neurosurg, Chicago, IL 60637 USA Univ Chicago Hosp, Dept Pathol, Chicago, IL 60637 USA Univ Chicago Hosp Chicago IL USA 60637 Dept Pathol, Chicago, IL 60637 USA Univ Chicago Hosp, Dept Neurol, Chicago, IL 60637 USA Univ Chicago Hosp Chicago IL USA 60637 Dept Neurol, Chicago, IL 60637 USA Michael Reese Hosp & Med Ctr, Dept Radiat Oncol, Chicago, IL 60616 USA Michael Reese Hosp & Med Ctr Chicago IL USA 60616 , Chicago, IL 60616 USA Michael Reese Hosp & Med Ctr, Dept Pathol, Chicago, IL 60616 USA Michael Reese Hosp & Med Ctr Chicago IL USA 60616 , Chicago, IL 60616 USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
fascicolo: 3, volume: 23, anno: 2000,
pagine: 222 - 226
SICI:
0277-3732(200006)23:3<222:LGGTWA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUVENILE PILOCYTIC ASTROCYTOMA; CEREBRAL HEMISPHERES; COMPUTED-TOMOGRAPHY; SUPRATENTORIAL ASTROCYTOMAS; CEREBELLAR ASTROCYTOMAS; PROGNOSTIC FACTORS; RADIOTHERAPY; IRRADIATION; MANAGEMENT; SURVIVAL;
Keywords:
glioma; radiotherapy; outcome; progression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Mansur, DB Univ Chicago Hosp, Dept Radiat & Cellular Oncol, 5758 S Maryland Ave,MC 9006, Chicago, IL 60637 USA Univ Chicago Hosp 5758 S Maryland Ave,MC 9006 Chicago IL USA 60637
Citazione:
D.B. Mansur et al., "Low grade gliomas treated with adjuvant radiation therapy in the modern imaging era", AM J CL ONC, 23(3), 2000, pp. 222-226

Abstract

The purpose of this study is to evaluate tumor control and failure patterns in patients with low grade gliomas treated with surgery and conventional adjuvant radiation therapy. Twenty-eight patients with low grade gliomas (7grade I, 21 grade II) were retrospectively evaluated. Extent of resection was gross total (3), subtotal (17), and biopsy alone (8). All grade I tumors underwent subtotal resection. Median radiation therapy dose was 54 Gy delivered to localized fields. Tumor control and patterns of failure were determined from follow-up computed tomography and/or magnetic resonance scans. Median follow-up was 86 months (range, 2.4-177 months). Thirteen patients (46%) (four grade I, nine grade II) developed tumor progression. The 5-year actuarial progression-free survival rates for grade I and grade II patientswere 86% and 51%, respectively. Corresponding 5-year actuarial survival rates were 100% and 70%. All recurrences were within the treated volume. Our results reveal that conventional adjuvant radiation therapy is associated with high rates of local tumor progression in both grade II and incompletelyresected grade I low grade gliomas. Alternative strategies need to be explored in these patients in an effort to improve tumor control and outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:31:30