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Titolo:
Accuracy of C-13-urea breath test in clinical use for diagnosis of Helicobacter pylori infection
Autore:
Riepl, RL; Folwaczny, C; Otto, B; Klauser, A; Blendinger, C; Wiebecke, B; Konig, A; Lehnert, P; Heldwein, W;
Indirizzi:
Univ Munich, Med Klin, Klinikum Innenstadt, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 m Innenstadt, D-80336 Munich, Germany Univ Munich, Inst Pathol, Klinikum Innenstadt, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 m Innenstadt, D-80336 Munich, Germany Max Von Pettenkofer Inst, D-8000 Munich, Germany Max Von Pettenkofer InstMunich Germany D-8000 t, D-8000 Munich, Germany
Titolo Testata:
ZEITSCHRIFT FUR GASTROENTEROLOGIE
fascicolo: 1, volume: 38, anno: 2000,
pagine: 13 - 19
SICI:
0044-2771(200001)38:1<13:AOCBTI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONDISPERSIVE INFRARED SPECTROMETRY; ULCER DISEASE; UREA; ERADICATION; RANITIDINE; HISTOLOGY; GASTRITIS; STANDARD; CULTURE; THERAPY;
Keywords:
accuracy; C-13; Helicobacter pylori; stable isotope; sensitivity; specificity; urea breath test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Riepl, RL Univ Munich, Med Klin, Klinikum Innenstadt, Ziemssenstr 1, D-80336 Munich,Germany Univ Munich Ziemssenstr 1 Munich Germany D-80336 Munich,Germany
Citazione:
R.L. Riepl et al., "Accuracy of C-13-urea breath test in clinical use for diagnosis of Helicobacter pylori infection", Z GASTROENT, 38(1), 2000, pp. 13-19

Abstract

The C-13-urea breath test (UBT) is a noninvasive test for diagnosis of Helicobacter pylori infection of gastric mucosa. The aim of this prospective study was to assess the accuracy of a simple UBT in clinical routine use. Methods: The study population comprised of 100 patients (49 f, 51 m) requiring diagnostic upper CT endoscopy. One biopsy specimen was taken from the gastric anll urn, body and fundus, respectively, for standard histological examination and one additional, specimen from each location was transformedinto transport medium for cultivation of H. pylori. After vaccination of the culture plates the biopsies were tested for urease activity (UAT). Afterrecovery from endoscopy the patients had to pass an one liter endexspiratory breath sample before and 15 min after drinking 200 mi orange juice, pH 3.6, containing 75 mg of C-13-urea. (CO2)-C-13 was measured in the breath samples using isotope-selective nondispersive infrared spectrometry. Results: Defining gold standard groups with all biopsy tests (from antrum and corpus) positive or negative die (CO2)-C-13 delta over baseline (DOB) cut-off level of UBT was set at 6.5 parts per thousand in order to best discriminate positive from negative patients (ROC analysis). UBT was positive in 37% of all subjects. Taken UAT and histological examination together (positive when both tests were positive) UBT displayed a sensitivity of 92%, a specificity of 94%, a positive predictive value of 89%, and a negative predictive value of 94%. When including the results of culture sensitivity and negative predictive value reached almost 100%. The mean of the (CO2)-C-13-DOB values from H. pylori-positive duodenal or gastric ulcer patients did not differ from controls (H, pylori-positive patients without leasions). The (CO2)-C-13-DOB values of the ulcer group were correlated significantly withthe active inflammatory component of gastritis in antrum, corpus, and fundus. Conclusion: UBT with this setup detects H. pylori infection in clinical routine use with high accuracy. The increase of exhaled (CO3)-C-13 does not predict ulcer disease but reflects the de -gree of active inflammation of gastric mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:04:46