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Titolo:
Effects of molybdate and pentachlorophenol on the sulfation of acetaminophen
Autore:
Boles, JW; Klaassen, CD;
Indirizzi:
Univ Kansas, Med Ctr, Ctr Environm & Occupat Hlth, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 Therapeut, Kansas City, KS 66160 USA
Titolo Testata:
TOXICOLOGY
fascicolo: 1, volume: 146, anno: 2000,
pagine: 23 - 35
SICI:
0300-483X(20000420)146:1<23:EOMAPO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED-RAT-LIVER; ADENOSINE 3'-PHOSPHATE 5'-PHOSPHOSULFATE; BILIARY-EXCRETION; INORGANIC SULFATE; HYDROXAMIC ACIDS; INVIVO; GLUCURONIDATION; HARMOL; CONJUGATION; METABOLISM;
Keywords:
molybdate; pentachlorophenol; acetaminophen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Klaassen, CD Univ Kansas, Med Ctr, Ctr Environm & Occupat Hlth, Dept Pharmacol Toxicol & Therapeut, 3901 Rainbow Blvd, Kansas City, KS 66160 USA UnivKansas 3901 Rainbow Blvd Kansas City KS USA 66160 60 USA
Citazione:
J.W. Boles e C.D. Klaassen, "Effects of molybdate and pentachlorophenol on the sulfation of acetaminophen", TOXICOLOGY, 146(1), 2000, pp. 23-35

Abstract

Pentachlorophenol (PCP) is an inhibitor of phenol-sulfotransferases and has been used to ascertain the role of sulfation in toxicology. Recently, molybdate has been shown to inhibit the sulfation of various chemicals by decreasing hepatic concentrations of the cosubstrate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The purpose of this study was to compare the effectiveness of these two chemicals in inhibiting the sulfation of various doses ofacetaminophen (AA) in the rat. PCP (40 mu mol/kg) decreased the 2-h combined biliary and urinary excretion of AA-sulfate by 78, 83, 84, and 47% of the 0.1, 0.3, 1, and 3 mmol/kg doses of AA, respectively. Molybdate (7.5 mmol/kg) decreased the sulfation of these same doses of AA by SD. 65, 62, and 81%, respectively. These data indicate that PCP is more effective in decreasing the sulfation of low than high doses of AA, which may result from less AA, at lower doses, to compete with PCP for sulfotransferases. Conversely, molybdate is more effective in decreasing sulfation of high rather than lowdoses of AA because molybdate decreases sulfate availability and decreasesPAPS synthesis. More PAPS is required for the sulfation of high rather than low doses of AA. Therefore, PCP inhibits sulfation more effectively at low doses of AA when sulfation is limited by sulfotransferases, and molybdateinhibits sulfation more effectively at high doses of AA when sulfation is limited by PAPS. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:58:23