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Titolo:
Antithrombotic treatment (argatroban vs. heparin) in coronary angioplasty in angina pectoris: Effects on inflammatory, hemostatic, and endothelium-derived parameters
Autore:
Suzuki, S; Matsuo, T; Kobayashi, H; Matsuo, M; Shimamo, C; Koide, M; Sakamoto, S;
Indirizzi:
Hyogo Prefectural Awaji Hosp, Sumoto, Hyogo 6560013, Japan Hyogo Prefectural Awaji Hosp Sumoto Hyogo Japan 6560013 go 6560013, Japan
Titolo Testata:
THROMBOSIS RESEARCH
fascicolo: 4, volume: 98, anno: 2000,
pagine: 269 - 279
SICI:
0049-3848(20000515)98:4<269:AT(VHI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC THROMBIN INHIBITOR; CARDIOVASCULAR-DISEASE; RECOMBINANT HIRUDIN; BALLOON ANGIOPLASTY; ACTIVATION; RESTENOSIS; EFFICACY; COMPLEX; RISK;
Keywords:
angina pectoris; coronary angioplasty; heparin; argatroban; hemostasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuo, T Hyogo Prefectural Awaji Hosp, 1-6-6 Shimogamo, Sumoto, Hyogo 6560013, Japan Hyogo Prefectural Awaji Hosp 1-6-6 Shimogamo Sumoto Hyogo Japan6560013
Citazione:
S. Suzuki et al., "Antithrombotic treatment (argatroban vs. heparin) in coronary angioplasty in angina pectoris: Effects on inflammatory, hemostatic, and endothelium-derived parameters", THROMB RES, 98(4), 2000, pp. 269-279

Abstract

To evaluate the suitability of two anticoagulants (heparin vs. argatroban)as adjunctive drugs during and after elective conventional percutaneous transluminal coronary angioplasty, we compared the changes in inflammatory, hemostatic, and endothelium-derived markers in groups of patients with stable angina treated with the two drugs during percutaneous transluminal coronary angioplasty, Twenty-seven patients were randomly allocated to either group 1 (15 patients who received an empiric dose of heparin and aspirin as anticoagulant), or group 2 (12 patients who received an alternative regimen of argatroban and aspirin), Both drugs were administered as a bolus followedby continuous infusion for 96 hours during and after percutaneous transluminal coronary angioplasty. There were no differences in the inflammatory response induced by percutaneous transluminal coronary angioplasty in both groups, but the fibrinogen concentration significantly decreased during percutaneous transluminal coronary angioplasty in group 2, Decreased platelet counts and increased mean platelet volume were observed during percutaneous transluminal coronary angioplasty in both groups. The levels of prothrombin fragment 1+2 and thrombin antithrombin III complex increased markedly during percutaneous transluminal coronary angioplasty. Group 2 showed a more rapid return to the baseline levels of these two markers than group 1. Secondary fibrinolysis was evidenced by a steep increase of D-dimer after percutaneous transluminal coronary angioplasty in both groups. In contrast to the significant decrease in antithrombin activities during percutaneous transluminal coronary angioplasty in group 1, no marked change in these markers wasfound in group 2. Although the levels of von Willebrand factor and plasminogen activator inhibitor-1 showed essentially the same changes in both groups during and after percutaneous transluminal coronary angioplasty, more markedly increased levels of tissue type plasminogen activator and type plasminogen activator-plasminogen activator inhibitor-1 complex after percutaneous transluminal coronary angioplasty were found in group 1 than in group 2. While neither drug had any effect on the percutaneous transluminal coronary angioplasty-induced inflammatory response, argatroban may more effectively inhibit the generated thrombin and prevent antithrombin consumption during and after percutaneous transluminal coronary angioplasty. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 13:48:47