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Titolo:
Effect of a genetic polymorphism of CYP1A2 inducibility on the steady state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia
Autore:
Mihara, K; Suzuki, A; Kondo, T; Yasui, N; Furukori, H; Nagashima, U; Ono, S; Kaneko, S; Otani, K; Inoue, Y;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Yamagata Univ, Sch Med, Dept Neuropsychiat, Yamagata 99023, Japan YamagataUniv Yamagata Japan 99023 Neuropsychiat, Yamagata 99023, Japan Yoshitomi Pharmaceut Ind Ltd, Pharmaceut Technol Ctr, Fukuoka, Japan Yoshitomi Pharmaceut Ind Ltd Fukuoka Japan Technol Ctr, Fukuoka, Japan
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 3, volume: 22, anno: 2000,
pagine: 245 - 249
SICI:
0163-4356(200006)22:3<245:EOAGPO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE HYDROXYLATION PHENOTYPE; POOR METABOLIZERS; SMOKING; CAFFEINE; CHINESE; CYP2D6; ALLELE; PHARMACOKINETICS; DISPOSITION; SERUM;
Keywords:
CYP1A2; genetic polymorphism; haloperidol; reduced haloperidol; steady state plasma concentration;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Mihara, K Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 mori 0368562, Japan
Citazione:
K. Mihara et al., "Effect of a genetic polymorphism of CYP1A2 inducibility on the steady state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia", THER DRUG M, 22(3), 2000, pp. 245-249

Abstract

The effect of a genetic polymorphism of inducibility of cytochrome P450 (CYP) 1A2 on the steady state plasma concentrations (Css) of haloperidol and reduced haloperidol was studied to clarify if these Css are dependent on the CYP1A2 activity. The subjects were 101 Japanese schizophrenic inpatients receiving oral haloperidol 12 mg/d. The Css of haloperidol and reduced haloperidol were measured in duplicate by high performance liquid chromatographic method, and were corrected to the mean body weight. A point mutation from guanine (wild-type) to adenine (mutated-type) at position - 2964 in the 5'-flanking region of CYP1A2 gene was identified by polymerase chain reaction (PCR)-fragrment length polymorphism method. Based on the present results,i.e., significant effects of CYP2D6 genotypes on the Css of haloperidol and reduced haloperidol, analyses were separately performed in two groups, i.e., patients with 0 mutated allele of the CYP2D6 (41 cases) and those with 1 or 2 mutated alleles (10 cases). Subjects in each CYP2D6 genotype group consisted of 4 subgroups according to smoking habit and the presence of the mutated allele of the CYP1A2. Neither the Css of haloperidol nor that of reduced haloperidol significantly differed among the 4 subgroups in either CYP2D6 genotype group. The present study thus suggests that the CYP1A2 activity does not play an important role in controlling the Css of haloperidol orreduced haloperidol.

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Documento generato il 19/01/20 alle ore 20:30:15