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Titolo:
Repeated administration of methamphetamine damages cells in the somatosensory cortex: Overlap with cytochrome oxidase-rich barrels
Autore:
ODell, SJ; Marshall, JF;
Indirizzi:
Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA Univ CalifIrvine Irvine CA USA 92697 obiol & Behav, Irvine, CA 92697 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 37, anno: 2000,
pagine: 32 - 37
SICI:
0887-4476(200007)37:1<32:RAOMDC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-HYDROXYLASE ACTIVITY; RAT-BRAIN; STRIATAL DOPAMINE; UPTAKE SITES; FLUORO-JADE; NEUROTOXICITY; GLUTAMATE; NEURONS; DEGENERATION; DISSOCIATION;
Keywords:
parietal cortex; neurotoxicity; amphetamine; psychostimulant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: O'Dell, SJ Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USAUniv Calif Irvine Irvine CA USA 92697 av, Irvine, CA 92697 USA
Citazione:
S.J. O'Dell e J.F. Marshall, "Repeated administration of methamphetamine damages cells in the somatosensory cortex: Overlap with cytochrome oxidase-rich barrels", SYNAPSE, 37(1), 2000, pp. 32-37

Abstract

Multiple injections of methamphetamine (mAMPH) cause degeneration of neurons in rat primary somatosensory cortex (Par1). These degenerating cells canbe labeled histochemically with the fluorochrome dye, Fluoro-Jade (FJ). This area of Par1 also contains the representation of the mystacial vibrissae. Neurons in this area of Par1 receiving projections derived from the vibrissae are arranged in discrete functional units ("barrels"), which are revealed by cytochrome oxidase CCO) histochemistry. Here, rats given mAMPH (fourinjections of 4 mg/kg, sc, 2-h intervals between injections) showed FJ-positive neurons in Par1 that were located predominantly near the perimeter ofthe CO-dense barrels. Thus, the Par1 neurons damaged by multiple administration of mAMPH are located within whisker barrels. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:42:44