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Titolo:
Morphology of layer III pyramidal neurons is altered following induction of LTP in sensorimotor cortex of the freely moving rat
Autore:
Ivanco, TL; Racine, RJ; Kolb, B;
Indirizzi:
McMaster Univ, Dept Psychol, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada niv, Dept Psychol, Hamilton, ON, Canada Univ Lethbridge, Dept Psychol & Neurosci, Lethbridge, AB T1K 3M4, Canada Univ Lethbridge Lethbridge AB Canada T1K 3M4 thbridge, AB T1K 3M4, Canada
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 37, anno: 2000,
pagine: 16 - 22
SICI:
0887-4476(200007)37:1<16:MOLIPN>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RABBIT FOLLOWING STIMULATION; MOTOR CORTEX; HORIZONTAL CONNECTIONS; SYNAPTIC TRANSMISSION; LASTING POTENTIATION; MAINTENANCE PHASE; PERFORANT PATH; DENTATE GYRUS; BRAIN;
Keywords:
long-term potentiation; spine; dendrite; Golgi; motor cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ivanco, TL 2217 Beckman Inst, 405 N Mathews, Urbana, IL 61801 USA 2217 Beckman Inst 405 N Mathews Urbana IL USA 61801 L 61801 USA
Citazione:
T.L. Ivanco et al., "Morphology of layer III pyramidal neurons is altered following induction of LTP in sensorimotor cortex of the freely moving rat", SYNAPSE, 37(1), 2000, pp. 16-22

Abstract

The organization of specific cortical connections can be altered by sensory and motor experience. These changes are believed to result from activity-dependent changes in synaptic connectivity, similar to those induced in thehippocampus by high-frequency stimulation in long-term potentiation (LTP) experiments. If similar mechanisms are involved, then neocortical LTP induction may induce some of the same morphological changes that are seen following learning. We induced LTP in the contralateral sensorimotor cortex by repeated, daily tetanization of the corpus callosum in chronically implanted,freely moving rats. Anatomical results showed that the LTP induction was associated with alterations in dendrite morphology and increased spine density. These changes are qualitatively and quantitatively similar to those commonly observed, in studies in which rats are housed in complex environments. The similarity of results following exposure to complex environments and after LTP induction in the neocortex may indicate a reliance on the same cellular mechanisms in both situations. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:12:53