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Titolo:
Essential role for cholesterol in entry of mycobacteria into macrophages
Autore:
Gatfield, J; Pieters, J;
Indirizzi:
Basel Inst Immunol, CH-4005 Basel, Switzerland Basel Inst Immunol Basel Switzerland CH-4005 CH-4005 Basel, Switzerland
Titolo Testata:
SCIENCE
fascicolo: 5471, volume: 288, anno: 2000,
pagine: 1647 - 1650
SICI:
0036-8075(20000602)288:5471<1647:ERFCIE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GREEN FLUORESCENT PROTEIN; NONOPSONIC BINDING; TUBERCULOSIS; MEMBRANE; BIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Pieters, J Basel Inst Immunol, Grenzacherstr 487, CH-4005 Basel, Switzerland Basel Inst Immunol Grenzacherstr 487 Basel Switzerland CH-4005
Citazione:
J. Gatfield e J. Pieters, "Essential role for cholesterol in entry of mycobacteria into macrophages", SCIENCE, 288(5471), 2000, pp. 1647-1650

Abstract

Mycobacteria are intracellular pathogens that can invade and survive within host macrophages, thereby creating a major health problem worldwide. The molecular mechanisms involved in mycobacterial entry are still poorly characterized. Here we report that cholesterol is essential for uptake of mycobacteria by macrophages. Cholesterol accumulated at the site of mycobacterialentry, and depleting plasma membrane cholesterol specifically inhibited mycobacterial uptake. Cholesterol also mediated the phagosomal association ofTACO, a coat protein that prevents degradation of mycobacteria in lysosomes. Thus, by entering host cells at cholesterol-rich domains of the plasma membrane, mycobacteria may ensure their subsequent intracellular survival inTACO-coated phagosomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:10:42