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Titolo:
Fenfluramine challenge in unipolar depression with and without anger attacks
Autore:
Fava, M; Vuolo, RD; Wright, EC; Nierenberg, AA; Alpert, JE; Rosenbaum, JF;
Indirizzi:
Massachusetts Gen Hosp, Depress Clin & Res Program, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Program, Boston, MA 02114 USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 1, volume: 94, anno: 2000,
pagine: 9 - 18
SICI:
0165-1781(20000424)94:1<9:FCIUDW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUOXETINE TREATMENT; PROLACTIN RESPONSE; DISORDERS; QUESTIONNAIRE; AGGRESSION;
Keywords:
aggression; depression; fenfluramine; prolactin; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Fava, M Massachusetts Gen Hosp, Depress Clin & Res Program, WACC 812,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp WACC 812,15 Parkman St Boston MA USA 02114
Citazione:
M. Fava et al., "Fenfluramine challenge in unipolar depression with and without anger attacks", PSYCHIAT R, 94(1), 2000, pp. 9-18

Abstract

We have previously hypothesized that patients with major depression and anger attacks may have a greater central serotonergic dysregulation than depressed patients without such attacks. We wanted to compare the prolactin response to fenfluramine challenge, as an indirect measure of central serotonergic function, in depressed patients with and without anger attacks. We recruited 37 outpatients (22 men and 15 women; mean age: 39.5 +/- 10.5) with DSM-III-R major depressive disorder, diagnosed with the SCID-F, Their initial 17-item Hamilton Rating Scale for Depression score was greater than or equal to 16. Patients were classified as either having or not having anger attacks with the Anger Attacks Questionnaire. All patients received a single-blind placebo challenge followed by a fenfluramine challenge (60 mg orally)the next day. Plasma prolactin measurements were obtained with double antibody radioimmunoassay before and after both placebo and fenfluramine challenges, and fenfluramine and norfenfluramine blood levels after each challenge were determined by gas chromatography. Of the 37 study participants, 17 (46%) were classified as having anger attacks. There were no significant differences in age, Sender, fenfluramine, or norfenfluramine blood levels between depressed patients with and without anger attacks. Depressed patients with anger attacks showed a significantly blunted prolactin response to fenfluramine challenge compared to patients without anger attacks. As previous studies have shown blunted prolactin responses to fenfluramine in impulsiveaggression among patients with personality disorders, our results support our hypothesis that depressed patients with anger attacks may have a relatively greater serotonergic dysregulation than depressed patients without these attacks. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 20/09/20 alle ore 20:18:01