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Titolo:
The role of photoreceptors in the control of refractive state
Autore:
Crewther, DP;
Indirizzi:
La Trobe Univ, Sch Psychol Sci, Bundoora, Vic 3083, Australia La Trobe Univ Bundoora Vic Australia 3083 , Bundoora, Vic 3083, Australia
Titolo Testata:
PROGRESS IN RETINAL AND EYE RESEARCH
fascicolo: 4, volume: 19, anno: 2000,
pagine: 421 - 457
SICI:
1350-9462(200007)19:4<421:TROPIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL-PIGMENT EPITHELIUM; FORM-DEPRIVATION MYOPIA; CHOROIDAL BLOOD-FLOW; MARMOSET CALLITHRIX-JACCHUS; INTRAVITREAL KAINIC ACID; OPTIC-NERVE SECTION; LID-SUTURE MYOPIA; EYE GROWTH; OCULAR DEVELOPMENT; SPECTACLE LENSES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
173
Recensione:
Indirizzi per estratti:
Indirizzo: Crewther, DP La Trobe Univ, Sch Psychol Sci, Bundoora, Vic 3083, AustraliaLa Trobe Univ Bundoora Vic Australia 3083 ic 3083, Australia
Citazione:
D.P. Crewther, "The role of photoreceptors in the control of refractive state", PROG RET EY, 19(4), 2000, pp. 421-457

Abstract

The current state of research into experimentally induced refractive errors is reviewed. The area is: analysed in three components - the transductionof defocus or deprivation. the vector for transmitting the error message from the retina to the outer tunics of the eve. and the identity of the effector for causing growth modulation in the sclera. Anatomical, pharmacological, electrophysiological and optical factors are considered in terms of which elements of the retina are necessary to support a refractive response todeprivation or defocus. Two of the current models are discussed - one emphasizing the role of the choroid in effecting ocular and refractive change, while the second model approaches the problem from the aspect of scleral changes that are associated with growth adaptation without emphasis on the error detection mechanism. A third model is proposed in which the error signal for deprivation or defocus is detected in the outer retina and where error is translated through separate signals for stimulus brightening and darkening into a net signal for fluid flow across and under the active control of the retinal pigment epithelium with the fluid communication between the vitreous chamber and the choroidal lymphatics. The directions of research both fundamental and clinical which are needed to create pharmaceutical or environmental solutions to refractive control are discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:01:04