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Titolo:
A comparison of the effects of clozapine and olanzapine on the EEG in patients with schizophrenia
Autore:
Schuld, A; Kuhn, M; Haack, M; Kraus, T; Hinze-Selch, D; Lechner, C; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
PHARMACOPSYCHIATRY
fascicolo: 3, volume: 33, anno: 2000,
pagine: 109 - 111
SICI:
0176-3679(200005)33:3<109:ACOTEO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC DRUG; SEIZURES; ABNORMALITIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
A. Schuld et al., "A comparison of the effects of clozapine and olanzapine on the EEG in patients with schizophrenia", PHARMACOPS, 33(3), 2000, pp. 109-111

Abstract

Clozapine is known to induce epileptic seizures and changes in EEG-patterns, including slowing and the appearance of epileptiform activity. Olanzapine, a new antipsychotic drug, shares many pharmacological and clinical properties with clozapine. However, in patients treated with olanzapine, no caseof seizure induction has been reported so far, and the EEG has not been studied systematically. We examined the EEGs of patients with schizophrenia treated with either olanzapine (N=9) or clozapine (N=9) prior to medication and 3 to 7 weeks afterwards. Clozapine induced significant EEC slowing present in 78% of the patients, and definite epileptiform activity appeared in 33%. Olanzapine also induced significant EEG slowing, but less frequently (in 44% of the patients) and less pronounced than clozapine. Olanzapine had no significant effect an epileptiform activity, but in one patient, an isolated sharp/stow-wave complex was observed. These preliminary data suggest that olanzapine induces EEG slowing to a lower extent than clozapine. Olanzapine's possible effect an the seizure threshold deserves further attention.

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Documento generato il 19/01/20 alle ore 06:39:00