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Titolo:
Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats: Antioxidant defense system
Autore:
Somani, SM; Husain, K; Whitworth, C; Trammell, GL; Malafa, M; Rybak, LP;
Indirizzi:
So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 acol, Springfield, IL 62794 USA So Illinois Univ, Sch Med, Dept Surg, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 Surg, Springfield, IL 62794 USA Univ Illinois, Dept Chem, Springfield, IL 62794 USA Univ Illinois Springfield IL USA 62794 pt Chem, Springfield, IL 62794 USA
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 5, volume: 86, anno: 2000,
pagine: 234 - 241
SICI:
0901-9928(200005)86:5<234:DPBLAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE PROTECTION; LIPID-PEROXIDATION; CIS-PLATINUM; SUPEROXIDE-DISMUTASE; REDUCED GLUTATHIONE; ANTITUMOR-ACTIVITY; OXIDATIVE STRESS; INDUCED TOXICITY; KIDNEY CORTEX; ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Somani, SM So Illinois Univ, Sch Med, Dept Pharmacol, POB 19629, Springfield, IL 62794 USA So Illinois Univ POB 19629 Springfield IL USA 62794 L 62794 USA
Citazione:
S.M. Somani et al., "Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats: Antioxidant defense system", PHARM TOX, 86(5), 2000, pp. 234-241

Abstract

This study was designed to investigate the role of graded doses of lipoic acid pretreatment against cisplatin-induced nephrotoxicity. Male Wistar rats were divided into six groups and treated as follows: 1) vehicle (saline) control; 2) cisplatin (16 mg/kg, intraperitoneally); 3) lipoic acid (100 mg/kg, intraperitoneally); 4) cisplatin plus lipoic acid (25 mg/ kg); 5) cisplatin plus lipoic acid (50 mg/kg) and 6) cisplatin plus lipoic acid (100 mg/kg). Rats were sacrificed three days after treatment, and plasma as well as kidneys were isolated and analyzed. Plasma creatinine increased (677% of control) following cisplatin administration alone which was decreased by lipoic acid in a dose-dependent manner. Cisplatin-treated rats showed a depletion of renal glutathione (GSH), increased oxidized GSH and decreased GSH/GSH oxidized ratio (62%, 166% and 62% of control), respectively which were restored with lipoic acid pretreatment. Renal superoxide dismutase, catalase, glutathione peroxidase (GSH peroxidase) and glutathione reductase activities decreased (62%, 75%, 62% and 80% of control), respectively and malondialdehyde content increased (204% of control) following cisplatin administration, which were restored with increasing doses of lipoic acid. The renal platinum concentration increased following cisplatin administration, which was possibly decreased by chelation with lipoic acid. The data suggest that the graded doses of lipoic acid effectively prevented a decrease in renal antioxidant defense system and prevented an increase in lipid peroxidation, platinum content and plasma creatinine concentrations in a dose-dependent manner.

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Documento generato il 14/08/20 alle ore 17:07:35