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Titolo:
Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?
Autore:
Akopian, A; Demulder, A; Ouriaghli, F; Corazza, F; Fondu, P; Bergmann, P;
Indirizzi:
Free Univ Brussels, CHU Brugmann, Lab Expt Hematol, B-1020 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1020 tol, B-1020 Brussels, Belgium
Titolo Testata:
PEPTIDES
fascicolo: 4, volume: 21, anno: 2000,
pagine: 559 - 564
SICI:
0196-9781(200004)21:4<559:EOCOHO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; MULTINUCLEATED CELLS; SIGNAL TRANSDUCTION; MARROW CULTURES; RECEPTORS;
Keywords:
CGRP; osteoclast-like cell; disuse osteoporosis; neurological disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Demulder, A Free Univ Brussels, CHU Brugmann, Lab Expt Hematol, 4 Pl Van Gehuchten, B-1020 Brussels, Belgium Free Univ Brussels 4 Pl Van Gehuchten Brussels Belgium B-1020
Citazione:
A. Akopian et al., "Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?", PEPTIDES, 21(4), 2000, pp. 559-564

Abstract

Osteoclast-like cell (OCL-like) differentiation is increased in long term cultures of bone marrow taken from paralyzed areas of paraplegic patients. Among the neuropeptides recently described in bone, calcitonin gene-relatedpeptide (CGRP) has been shown in animal studies to inhibit bone resorptionin vivo and OCL-like differentiation in vitro: its deficiency could thus be a link between the neural lesion and increased OCL-like production in paraplegia and some other neurologic disorders. We therefore investigated in this study the effects of CGRP on human OCL-like formation and found that itindeed has an inhibitory effect mediated at least in part via cAMP. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:17:25