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Titolo:
Kinetics of palmitic acid transport in insulin-dependent diabetic pregnancies: In vitro study
Autore:
Nandakumaran, M; Makhseed, MA; Al-Rayyes, S; Al-Yatama, M; Devarajan, L; Sugathan, T;
Indirizzi:
Kuwait Univ, Fac Med, Dept Obstet & Gynecol, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 ept Obstet & Gynecol, Safat 13110, Kuwait Kuwait Univ, Fac Med, Dept Paediat, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 ac Med, Dept Paediat, Safat 13110, Kuwait Kuwait Univ, Fac Med, Dept Community Med, Safat 13110, Kuwait Kuwait UnivSafat Kuwait 13110 , Dept Community Med, Safat 13110, Kuwait
Titolo Testata:
PEDIATRICS INTERNATIONAL
fascicolo: 3, volume: 42, anno: 2000,
pagine: 296 - 301
SICI:
1328-8067(200006)42:3<296:KOPATI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED HUMAN-PLACENTA; FREE FATTY-ACIDS; INVITRO; RAT;
Keywords:
diabetic pregnancy; human placenta; in vitro; palmitic acid; perfusion; transport kinetics; tritiated water;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nandakumaran, M Kuwait Univ, Fac Med, Dept Obstet & Gynecol, POB 24923, Safat 13110, Kuwait Kuwait Univ POB 24923 Safat Kuwait 13110 at 13110, Kuwait
Citazione:
M. Nandakumaran et al., "Kinetics of palmitic acid transport in insulin-dependent diabetic pregnancies: In vitro study", PEDIATR INT, 42(3), 2000, pp. 296-301

Abstract

Backgound: The paucity of data relating to transport kinetics of free fatty acids (FFA) in pregnant diabetic women prompted the undertaking of the present study. Methods: Transport kinetics of a model FFA, palmitic acid, have been investigated in Type I diabetic pregnancies, using in vitro perfusion of isolated placental lobules. National Cancer Tissue Culture medium diluted with Earle's buffered salt solution was used as the perfusate and control placentallobules were perfused for comparison. Results: In five Type I diabetic women, the palmitic acid transport fraction (TF) averaged 5.6+/-0.42% of injected maternal bolus dose, representing 11.8+/-2.1% that of tritiated water used as reference. In control perfusions (n=5), the palmitic acid TF represented 10.2+/-1.3% of tritiated water TF. Differential transport rates of palmitic acid for 10, 25, 50, 75 and 90% of efflux in fetal veins differed significantly from the corresponding values for tritiated water in both study and control series. However, palmitic acid transport rates for the various efflux fractions in the two series were not significantly different. For kinetic parameters, such as area under the curve, clearance, elimination constant, time for maximum response, absorption rate and elimination rate, the values for palmitic acid in the diabetic and control series also did not differ significantly. Conclusion: Transport kinetics of palmitic acid in Type I human diabetic pregnancies in in vitro conditions do not differ significantly from those observed in normal pregnancies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:45:47