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Titolo:
Inhalation of nebulized nitroglycerin in dogs with experimental pulmonary hypertension induced by U46619
Autore:
Gong, FQ; Shiraishi, H; Kikuchi, Y; Hoshina, M; Ichihashi, K; Sato, Y; Momoi, MY;
Indirizzi:
Jichi Med Sch, Dept Pediat, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan
Titolo Testata:
PEDIATRICS INTERNATIONAL
fascicolo: 3, volume: 42, anno: 2000,
pagine: 255 - 258
SICI:
1328-8067(200006)42:3<255:IONNID>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALED NITRIC-OXIDE; CONGENITAL HEART-DISEASE; SMOOTH-MUSCLE; ENDOTHELIAL-CELLS; RELAXING FACTOR; VASCULAR TONE; RELAXATION; IDENTIFICATION; INVOLVEMENT; U-46619;
Keywords:
nitroglycerin; pulmonary hypertension; U46619;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Shiraishi, H Jichi Med Sch, Dept Pediat, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 98, Japan
Citazione:
F.Q. Gong et al., "Inhalation of nebulized nitroglycerin in dogs with experimental pulmonary hypertension induced by U46619", PEDIATR INT, 42(3), 2000, pp. 255-258

Abstract

Background: Pulmonary hypertension (PH) causes mortality in some congenital and acquired heart and lung diseases. However, inhalation of NO gas requires complicated and expensive instruments and elaborate preparations to avoid toxic gas administration. We tested the effectiveness and safety of inhaled nebulized nitroglycerin (Neb-NTG) in dogs with experimental PH. Methods: Experimental PH was induced by continuous infusion of a thromboxane analog (U46619). The U46619 infusion rate was adjusted to maintain a systolic pulmonary artery pressure (PAP) at 40 mmHg in 10 anesthetized and mechanically ventilated dogs. Then, 20 mu g/kg of NTG liquid nebulized by compressed air was inhaled. Results: After infusion of U46619, the systolic, diastolic and mean PAP increased by 119%, 228% and 169%, respectively, and the systolic, diastolic and mean systemic arterial pressures (SAP) increased by 19%, 29% and 23%, respectively. The systolic pulmonary to systemic pressure ratio (Pp/Ps) and mean Pp/Ps increased by 83% and 113%, respectively, and the pulmonary vascular resistance (PVR), systemic vascular resistance (SVR) and pulmonary to systemic resistance ratio (Rp/Rs) increased by 341%, 100% and 145%, respectively. After inhalation of Neb-NTG in dogs with experimental PH, systolic, diastolic and mean PAP and PVR decreased by 25+/-4, 26+/-11, 25+/-9 and 31+/-21%, respectively. There were no significant changes in systolic, diastolicand mean SAP, SVR, cardiac output and plasma methemoglobin concentrations. The systolic and mean Pp/Ps decreased by 18+/-7 and 20+/-7%, respectively. The Rp/Rs decreased by 25+/-13%. Conclusions: The results of this study demonstrate that Neb-NTG is an effective and selective pulmonary vasodilator and may offer a new therapeutic option for PH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:10:10