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Titolo:
Infarct related artery patency: Relation to serial electropharmacological studies and outcome in patients with previous myocardial infarction and ventricular tachyarrhythmias
Autore:
Hoppe, UC; Haverkamp, W; Breithardt, G; Borggrefe, M;
Indirizzi:
Univ Munster, Dept Cardiol & Angiol, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 & Angiol, D-48129 Munster, Germany Univ Munster, Inst Arteriosklerosis Res, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 lerosis Res, D-4400 Munster, Germany
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 5, volume: 23, anno: 2000,
pagine: 854 - 862
SICI:
0147-8389(200005)23:5<854:IRAPRT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED ELECTRICAL-STIMULATION; CORONARY-ARTERY; ORAL SOTALOL; THROMBOLYTIC THERAPY; LATE POTENTIALS; ANTIARRHYTHMIC DRUGS; ANTEROGRADE FLOW; TERM MORTALITY; TACHYCARDIA; ARRHYTHMIAS;
Keywords:
infarct related artery; electrophysiological study; d,l-sotalol; myocardial infarction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Borggrefe, M Univ Munster, Dept Cardiol & Angiol, Albert Schweizer Str 33,D-48129 Munster, Germany Univ Munster Albert Schweizer Str 33 Munster Germany D-48129
Citazione:
U.C. Hoppe et al., "Infarct related artery patency: Relation to serial electropharmacological studies and outcome in patients with previous myocardial infarction and ventricular tachyarrhythmias", PACE, 23(5), 2000, pp. 854-862

Abstract

Evidence suggests that infarct related artery (IRA) patency may improve survival after acute myocardial infarction, which is thought to be partially due to a lower incidence of malignant ventricular tachyarrhythmias. However, little is known about the effect of IRA patency on antiarrhythmic drug response and long-term outcome in patients with previous infarction who already experienced sustained ventricular tachyarrhythmias, A total of 152 patients with remote myocardial infarction and documented ventricular tachycardia (VT) or ventricular fibrillation (VF) underwent coronary angiography and programmed ventricular stimulation before and after oral administration of d,l-sotalol (240-640 mg/day). D,1-sotalol suppressed inducibility of VT/VF in 37 (25.2%) patients. The IRA was patent in 38.1% of all patients. There was no significant difference in the frequency of drug response between patients with patent or occluded IRAs (26.8% vs 24.2%, P = 0.87). in patients with a patent IRA, d,l-sotalol fended to be more effective in the absence of a left ventricular aneurysm, although this difference did not reach statistical significance (P = 0.38). Ejection fraction and collateral blood flowhad no effect on drug response in the presence or absence of IRA patency. During follow-up (13.0 +/- 19.9 months) of 29 patients discharged on oral d,l-sotalol, 3 patients experienced symptomatic VT and 4 sudden death. Arrhythmia recurrence and death of all cause (n = 6) and cardiac death (n = 4) were independent of IRA patency status. IRA patency had no effect on short-term drug response to d,l-sotalol in patients with remote myocardial infarction and documented VT/VF. Long-term outcome of patients with sustained ventricular tachyarrhythmias is independent of IRA patency status. In contrast to a previous report, outcome of electropharmacological testing wets not predicted by the patency of the IRA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:38:48