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Titolo:
Regional differences in arrhythmogenic aftereffects of high intensity DC stimulation in the ventricles
Autore:
Kodama, I; Sakuma, I; Shibata, N; Knisley, SB; Niwa, R; Honjo, H;
Indirizzi:
Nagoya Univ, Environm Med Res Inst, Dept Circulat, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ulat, Nagoya, Aichi 4648601, Japan Nagoya Univ, Environm Med Res Inst, Dept Humoral Regulat, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ulat, Nagoya, Aichi 4648601, Japan Univ Tokyo, Grad Sch, Dept Precis Machinery Engn, Tokyo, Japan Univ TokyoTokyo Japan ad Sch, Dept Precis Machinery Engn, Tokyo, Japan Univ Tokyo, Fac Engn, Tokyo, Japan Univ Tokyo Tokyo JapanUniv Tokyo, Fac Engn, Tokyo, Japan Tokyo Womens Med Coll, Heart Inst Japan, Dept Cardiol, Tokyo, Japan Tokyo Womens Med Coll Tokyo Japan nst Japan, Dept Cardiol, Tokyo, Japan Univ Alabama, Div Cardiovasc Dis, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 iovasc Dis, Birmingham, AL 35294 USA
Titolo Testata:
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
fascicolo: 5, volume: 23, anno: 2000,
pagine: 807 - 817
SICI:
0147-8389(200005)23:5<807:RDIAAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFIBRILLATION-STRENGTH SHOCKS; ELECTRIC-FIELD STIMULATION; OPTICAL RECORDINGS; ACTION-POTENTIALS; MYOCARDIAL-CELLS; RABBIT HEART; MYOCYTES; MUSCLE; REPOLARIZATION; INDUCTION;
Keywords:
defibrillation; electroporation; voltage-sensitive dye; postshock arrhythmias;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kodama, I Nagoya Univ, Environm Med Res Inst, Dept Circulat, Nagoya, Aichi4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ya, Aichi 4648601, Japan
Citazione:
I. Kodama et al., "Regional differences in arrhythmogenic aftereffects of high intensity DC stimulation in the ventricles", PACE, 23(5), 2000, pp. 807-817

Abstract

Regional differences of the aftereffects of high intensity DC stimulation were investigated in isolated rabbit hearts stained with a voltage-sensitive dye (di-4-ANEPPS). Optical action potential signals were recorded from the epicardial surface of the right and left ventricular free wall (RVep, LVep) and from the right endocardial surface of the interventricular septum (IVS). Ten-millisecond monophasic DC stimulation (S-2, 20-120 V) was applied to the signal recording spots during the early plateau phase of the action potential induced by basic stimuli (S-1, 2.5 Hz). There was a Linear relationship between St voltage and the S-2 field intentisy (FI). S-1 caused postshock additional depolarization, giving rise to a prolongation of the shocked action potential. With S-2 greater than or equal to 40 V (Fi greater than or equal to similar to 20 V/cm), terminal repolarization of action potential wets inhibited, and subsequent postshock S-2 action potentials for 1-5 minutes were characterized by a decrease in the maximum diastolic potentialand a decrease in the amplitude and a slowing of their upstroke phase. Thehigher the S-1 voltage, the larger the aftereffects. The changes in postshock action potential configuration in RVep were significantly greater than those observed in LVep and IVS when compared at the same levels of St intensity. In RVep, 12 of 20 shocks of 120 V resulted in a prolonged refractoriness to S-1 (> 1 s), and the arrest was often followed by oscillation of membrane potential. Ventricular tachycardia or fibrillation ensued from the oscillation in five cases. No such long arrest or serious arrhythmias were elicited in LVep and NS. These results suggest that RVep is more susceptible than LVep and IVS for arrhythmogenic aftereffects of high intensity DC stimulation.

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Documento generato il 09/04/20 alle ore 13:16:41