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Titolo:
Occupational exposure to formaldehyde and wood dust and nasopharyngeal carcinoma
Autore:
Vaughan, TL; Stewart, PA; Teschke, K; Lynch, CF; Swanson, GM; Lyon, JL; Berwick, M;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98109 , Seattle, WA 98109 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Natl Canc Inst, Div Canc Epidemiol & Genet, Occupat Epidemiol Branch, Bethesda, MD USA Natl Canc Inst Bethesda MD USA ccupat Epidemiol Branch, Bethesda, MD USA Univ British Columbia, Dept Hlth Care & Epidemiol, Vancouver, BC V6T 1W5, Canada Univ British Columbia Vancouver BC Canada V6T 1W5 ver, BC V6T 1W5, Canada Univ Iowa, Dept Epidemiol, Iowa City, IA USA Univ Iowa Iowa City IA USAUniv Iowa, Dept Epidemiol, Iowa City, IA USA Michigan State Univ, Ctr Canc, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 Canc, E Lansing, MI 48824 USA Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 n Med, E Lansing, MI 48824 USA Univ Utah, Dept Family Med, Salt Lake City, UT USA Univ Utah Salt Lake City UT USA Dept Family Med, Salt Lake City, UT USA Mem Sloan Kettering Canc Res Ctr, New York, NY 10021 USA Mem Sloan Kettering Canc Res Ctr New York NY USA 10021 York, NY 10021 USA
Titolo Testata:
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
fascicolo: 6, volume: 57, anno: 2000,
pagine: 376 - 384
SICI:
1351-0711(200006)57:6<376:OETFAW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER RESPIRATORY-TRACT; SQUAMOUS-CELL CANCERS; UNITED-STATES; RISK-FACTORS; NONDIFFERENTIAL MISCLASSIFICATION; POOLED REANALYSIS; SINONASAL CANCER; NASAL CAVITY; MORTALITY; WORKERS;
Keywords:
occupational exposure; formaldehyde; wood dust;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Vaughan, TL Fred Hutchinson Canc Res Ctr, Program Epidemiol, MP-474,1100 Fairview Ave,POB 19024, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr MP-474,1100 Fairview Ave,POB 19024 Seattle WA USA 98109
Citazione:
T.L. Vaughan et al., "Occupational exposure to formaldehyde and wood dust and nasopharyngeal carcinoma", OCC ENVIR M, 57(6), 2000, pp. 376-384

Abstract

Objectives-To investigate whether occupational exposures to formaldehyde and wood dust increase the risk of nasopharyngeal cancer (NPC). Methods-A multicentred, population based case-control study was carried out at five cancer registries in the United States participating in the National Cancer Institute's SEER program. Cases (n=196) with a newly diagnosed NPC between 1987 and 1993, and controls (n=244) selected over the same period from the general population through random digit dialing participated in structured telephone interviews which inquired about suspected risk factorsfor the disease, including a lifetime history of occupational and chemicalexposure. Histological type of cancer was abstracted from clinical recordsof the registries. Potential exposure to formaldehyde and wood dust was assessed on a job by job basis by experienced industrial hygienists who were blinded as to case or control status. Results-For formaldehyde, after adjusting for cigarette use, race, and other risk factors, a trend of increasing risk of squamous and unspecified epithelial carcinomas was found for increasing duration (p=0.014) and cumulative exposure (p=0.033) but not for maximum exposure concentration. The odds ratio (OR) for people cumulatively exposed to >1.10 ppm-years was 3.0 (95% confidence interval (95% CI) 1.3 to 6.6) compared with those considered unexposed. In analyses limited to jobs considered definitely exposed, these trends became stronger. The associations were most evident among cigarette smokers. By contrast, there was no association between potential exposure to formaldehyde and undifferentiated and non-keratinising carcinomas. There was little evidence that exposure to wood dust increased risk of NPC, as modest crude associations essentially disappeared after control for potential exposure to formaldehyde. Conclusions-These results support the hypothesis that occupational exposure to formaldehyde, but not wood dust, increases risk of NPC. This association seems to be specific to squamous cell carcinomas. Established cohorts ofworkers exposed to formaldehyde and wood dust should continue to be monitored for NPC and other respiratory cancers. Future studies of NPC should take into account histological type in assessing risk from environmental and host factors.

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Documento generato il 08/07/20 alle ore 06:41:55