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Titolo:
Hypoxia influences enkephalin release in rats
Autore:
Chen, XQ; Du, JZ;
Indirizzi:
Zhejiang Univ, Coll Life Sci, Div Neurobiol & Physiol, Hangzhou 310027, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310027 ou 310027, Peoples R China
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 11, anno: 2000,
pagine: 1555 - 1557
SICI:
0959-4965(20000515)11:7<1555:HIERIR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; RECEPTOR-LIKE IMMUNOREACTIVITY; MESSENGER-RNAS; METHIONINE-ENKEPHALIN; PREPROENKEPHALIN-A; PROENKEPHALIN-A; GENE-EXPRESSION; STRESS; HORMONE; WITHDRAWAL;
Keywords:
adrenalectomy; endogenous opioids; glucocorticoids; hypoxia; leucine-enkephalin; median eminence; rat; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Du, JZ Zhejiang Univ, Coll Life Sci, Div Neurobiol & Physiol, Yuquan Campus, Hangzhou 310027, Peoples R China Zhejiang Univ Yuquan Campus Hangzhou Peoples R China 310027 China
Citazione:
X.Q. Chen e J.Z. Du, "Hypoxia influences enkephalin release in rats", NEUROREPORT, 11(7), 2000, pp. 1555-1557

Abstract

To investigate hypoxia effects on leucine-enkephalin (L-ENK) levels of median eminence (ME) of hypothalamus in rats, and the possible glucocorticoid involvement in modulation. Hypoxia was stimulated in a hypobaric chamber. L-ENK levels were measured by specific radioimmunoassay during acute, and a comparison of L-ENK alteration was taken for bilateral adrenalectomy (ADX) with or without a replacement of dexamethasone (DEX). Acute hypoxia 10.8% O-2 for 30 min and 2 h markedly enhanced L-ENK levels of ME from 23.99 +/- 7.25 in control to 51.26 +/ 16.96 (P < 0.01) and 53.29 +/- 26.10 ng/mg protein (P < 0.01), and acute hypoxia at 8.2% O-2 significantly increased L-ENK of ME to 36.76 +/- 15.25 (p < 0.05) and 32.09 +/- 3.58 ng/mg protein (p < 0.05). The increased L-ENK was returned to normoxic level when hypoxia (10.8% O-2) exposure lasted for 24 h. After ADX, 10.8% O-2 hypoxia induced a sharp decline of L-ENK in the ME, but this decline was completely reversed by treatment with DEX (500 mu g/rat, i.p.). Acute hypoxia increases L-ENK level of hypothalamic ME in rats, which may present a reduced and /or inhibitedrelease of L-ENK, acting through a fast negative feedback mechanism of acute hypoxia activated high circulating glucocorticoid level. NeuroReport 11:1555-1557 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:42:24