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Titolo:
Expression of connexin36 mRNA in adult rodent brain
Autore:
Parenti, R; Gulisano, M; Zappala, A; Cicirata, F;
Indirizzi:
Univ Catania, Dept Physiol Sci, I-95125 Catania, Italy Univ Catania Catania Italy I-95125 t Physiol Sci, I-95125 Catania, Italy
Titolo Testata:
NEUROREPORT
fascicolo: 7, volume: 11, anno: 2000,
pagine: 1497 - 1502
SICI:
0959-4965(20000515)11:7<1497:EOCMIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GAP JUNCTION PROTEINS; MESSENGER-RNAS; CULTURED ASTROCYTES; MEMBRANE CHANNEL; RAT-BRAIN; NEURONS; NEOCORTEX;
Keywords:
connexin; gap junction; in situ hybridization; mCx36; mouse; neuron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Cicirata, F Univ Catania, Dept Physiol Sci, Viale Andrea Doria 6, I-95125 Catania, Italy Univ Catania Viale Andrea Doria 6 Catania Italy I-95125 Italy
Citazione:
R. Parenti et al., "Expression of connexin36 mRNA in adult rodent brain", NEUROREPORT, 11(7), 2000, pp. 1497-1502

Abstract

A new member of the connexin gene family, named Connexin36 (Cx36) has, recently, been identified in rodents and shown to be preferentially, if not exclusively, expressed in neurones of the adult CNS. In this study we presenta detailed in situ hybridization analysis of the expression pattern of mouse Connexin 36 (mCx36) mRNA in the adult mouse brain, with particular regards to the correlation of mCx36 expression to specific neuronal cell classesand systems. We found that mCx36 was strongly and widely expressed in the brain, including areas where the presence of gap junctions was never detected before. Quantitative analysis of the hybridization signal indicated varying levels of expression in different areas. In particular mCx36 was highlyexpressed in the neurones at different levels of the motor pathway, the olfactory pathway, the hippocampus, and areas related to the generation of respiratory rhythm. On the contrary, mCx36 was more heterogeneously expressedin nuclei of the sensory pathways. These findings show that mCx36 is the first connexin specifically expressed in neuronal cells in the adult rodent brain. The profiles of expression clearly indicate that mCx36 might play specific roles within different neuronal systems. NeuroReport 11:1497-1502 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:01:32