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Titolo:
Expression of the interferon-gamma-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions
Autore:
Simpson, JE; Newcombe, J; Cuzner, ML; Woodroofe, MN;
Indirizzi:
Sheffield Hallam Univ, Div Biomed Sci, Sheffield S1 1WB, S Yorkshire, England Sheffield Hallam Univ Sheffield S Yorkshire England S1 1WB shire, England Neurol Inst, Multiple Sclerosis Lab, London, England Neurol Inst London England nst, Multiple Sclerosis Lab, London, England
Titolo Testata:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
fascicolo: 2, volume: 26, anno: 2000,
pagine: 133 - 142
SICI:
0305-1846(200004)26:2<133:EOTICI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MYELIN BASIC-PROTEIN; ADULT-RAT BRAIN; FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; CYTOKINE FAMILY; T-LYMPHOCYTES;
Keywords:
chemokines; IP-10; Mig; IFN-gamma; CXCR3; inflammation; multiple sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Woodroofe, MN Sheffield Hallam Univ, Div Biomed Sci, City Campus,Pond St, Sheffield S1 1WB, S Yorkshire, England Sheffield Hallam Univ City Campus,Pond St Sheffield S Yorkshire England S1 1WB
Citazione:
J.E. Simpson et al., "Expression of the interferon-gamma-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions", NEUROP AP N, 26(2), 2000, pp. 133-142

Abstract

The recruitment of leucocytes to sites of inflammation is an important feature of multiple sclerosis (MS) pathology. Chemokines are involved in the activation and specific directional migration of monocytes and T-lymphocytesto sites of inflammation. Using immunocytochemistry, the expression of thealpha-chemokines, interferon (IFN)-gamma-inducible protein-10 (IP-10) and monokine induced by IFN-gamma (Mig), and their receptor CXCR3 have been examined in post-mortem central nervous system (CNS) tissue from MS cases at different stages of lesion development. In actively demyelinating lesions both IP-10 and Mig protein were predominantly expressed by macrophages withinthe plaque and by reactive astrocytes in the surrounding parenchyma. CXCR3was expressed by T cells and by astrocytes within the plaque. Interferon-gamma may stimulate glial cells to express IP-10 and Mig, which continue thelocal inflammatory response by selectively recruiting activated T-lymphocytes into the CNS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:12:04