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Titolo:
Traumatic axonal injury: practical issues for diagnosis in medicolegal cases
Autore:
Geddes, JF; Whitwell, HL; Graham, DI;
Indirizzi:
St Bartholomews & royal London Sch Med & Dent, Dept Histopathol & Morbid Anat, London, England St Bartholomews & royal London Sch Med & Dent LondonEngland n, England Univ Auckland, Dept Pathol, Auckland 1, New Zealand Univ Auckland Auckland New Zealand 1 ept Pathol, Auckland 1, New Zealand Univ Glasgow, Inst Neurol Sci, Dept Neuropathol, Glasgow, Lanark, ScotlandUniv Glasgow Glasgow Lanark Scotland ropathol, Glasgow, Lanark, Scotland
Titolo Testata:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
fascicolo: 2, volume: 26, anno: 2000,
pagine: 105 - 116
SICI:
0305-1846(200004)26:2<105:TAIPIF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; CLOSED-HEAD INJURY; PIG OPTIC-NERVE; PERSISTENT VEGETATIVE STATE; SHAKEN BABY SYNDROME; BRAIN INJURY; CYTOSKELETAL CHANGES; IMAGING FINDINGS; STRETCH INJURY; BETA-APP;
Keywords:
assault; beta-amyloid precursor protein; diffuse axonal injury; head injuries; non-accidental injury;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Geddes, JF Royal London Hosp, Dept Morbid Anat, London E1 1BB, England Royal London Hosp London England E1 1BB ondon E1 1BB, England
Citazione:
J.F. Geddes et al., "Traumatic axonal injury: practical issues for diagnosis in medicolegal cases", NEUROP AP N, 26(2), 2000, pp. 105-116

Abstract

In the 25 years or so after the first clinicopathological descriptions of diffuse axonal injury (DAI), the criterion for diagnosing recent traumatic white matter damage was the identification of swollen axons ('bulbs') on routine or silver stains, in the appropriate clinical setting. In the last decade, however, experimental work has given us greater understanding of the cellular events initiated by trauma to axons, and this in turn has led to the adoption of immunocytochemical methods to detect markers of axonal damage in both routine and experimental work. These methods have shown that traumatic axonal injury (TAI) is much more common than previously realized, andthat what was originally described as DAI occupies only the most severe end of a spectrum of diffuse trauma-induced brain injury. They have also revealed a whole field of previously unrecognized white matter pathology, in which axons are diffusely damaged by processes other than head injury; this in turn has led to some terminological confusion in the literature. Neuropathologists are often asked to assess head injuries in a forensic setting: the diagnostic challenge is to sort out whether the axonal damage detected ina brain is indeed traumatic, and if so, to decide what - if anything - canbe inferred from it. The lack of correlation between well-documented histories and neuropathological findings means that in the interpretation of assault cases at least, a diagnosis of 'TAI' or 'DAI' is likely to be of limited use for medicolegal purposes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:48:28