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Titolo:
Amenorrhea-galactorrhea syndrome in tumours of the sella region
Autore:
Honegger, J; Petrick, M;
Indirizzi:
Univ Freiburg, Abt Allgemeine Neurochirurg, D-79106 Freiburg, Germany UnivFreiburg Freiburg Germany D-79106 hirurg, D-79106 Freiburg, Germany
Titolo Testata:
NERVENHEILKUNDE
fascicolo: 4, volume: 19, anno: 2000,
pagine: 198 - 204
SICI:
0722-1541(2000)19:4<198:ASITOT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
GER
Soggetto:
SURGICAL-TREATMENT; MANAGEMENT; PROLACTINOMAS; HYPERPROLACTINEMIA; BROMOCRIPTINE; HYPOPHYSITIS; MICROSURGERY;
Keywords:
pituitary tumour; amenorrhea; galactorrhea; hyperprolactinemia; hypogonadism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Honegger, J Univ Freiburg, Abt Allgemeine Neurochirurg, Breisacher Str 64 Neurozentrum, D-79106 Freiburg, Germany Univ Freiburg Breisacher Str 64 Neurozentrum Freiburg Germany D-79106
Citazione:
J. Honegger e M. Petrick, "Amenorrhea-galactorrhea syndrome in tumours of the sella region", NERVENHEILK, 19(4), 2000, pp. 198-204

Abstract

A prolactinoma is the prevailing cause of an amenorrhea-galactorrhea syndrome. Medical therapy with dopamine-agonists is the therapy of choice in prolactinomas. However, there are still indications for transsphenoidal surgery and under certain clinical circumstances, even primary surgery might be required. Following successful therapy with normalization of prolactin, normal menstrual cycles are generally restored and galactorrhea disappears. In non-functioning pituitary adenomas, amenorrhea-galactorrhea syndrome issecondary to pituitary stalk distortion and tumour mass effect. Nonfunctioning adenomas are usually associated with less than 10-fold elevated prolactin levels which allows differentiation from macroprolactinomas with excessively high prolactin levels. Nonfunctioning adenomas require surgical therapy. Menstrual cycle abnormalities in Gushing's disease are precipitated by hypercortisolism, galactorrhea is rarely observed in Gushing's disease. Autoimmune hypophysitis predominantly affects female patients and producesa pituitary mass. It is an increasingly recognized reason of amenorrhea and galactorrhea. Various other space-occupying lesions and tumours of the sella region can produce hyperprolactinaemia and hypogonadism. The frequency of these endocrine disturbances depends on the tumour entity. Hence, the presence of hyperprolactinaemia and hypogonadism is significant for differential diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:20:56