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Titolo:
Pharmaco-EEG test dose response predicts cholinesterase inhibitor treatment outcome in Alzheimer's disease
Autore:
Knott, V; Mohr, E; Mahoney, C; Ilivitsky, V;
Indirizzi:
Univ Ottawa, Royal Ottawa Hosp, Mental Hlth Res Inst, Dept Psychiat & Psychol, Ottawa, ON K1Z 7K4, Canada Univ Ottawa Ottawa ON Canada K1Z 7K4 Psychol, Ottawa, ON K1Z 7K4, Canada CroMedica Global, Victoria, BC, Canada CroMedica Global Victoria BC Canada oMedica Global, Victoria, BC, Canada
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 2, volume: 22, anno: 2000,
pagine: 115 - 122
SICI:
0379-0355(200003)22:2<115:PTDRPC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Keywords:
electroencephalography (EEG); dementia of the Alzheimer type (DAT); cholinesterase inhibitor; tetrahydroaminoacridine (THA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
0
Recensione:
Indirizzi per estratti:
Indirizzo: Knott, V Univ Ottawa, Royal Ottawa Hosp, Mental Hlth Res Inst, Dept Psychiat & Psychol, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada Univ Ottawa 1145Carling Ave Ottawa ON Canada K1Z 7K4 7K4, Canada
Citazione:
V. Knott et al., "Pharmaco-EEG test dose response predicts cholinesterase inhibitor treatment outcome in Alzheimer's disease", METH FIND E, 22(2), 2000, pp. 115-122

Abstract

Previous investigations have indicated that a single dose pharmaco-EEG maypredict the outcome of 4-7 weeks of tetrahydroaminoacridine (THA) treatment in dementia of the Alzheimer type (DAT). This open trial study further examined the relationship of quantitive EEG in relation to treatment responseby assessing 24 probable DAT patients at baseline, 2 h after their first oral dose (30 mg), and after 12 weeks of THA treatment. Compared to EEG norms, patients, in general, evidenced EEG slowing, as shown by excessive slow (circle minus) and diminished fast (alpha and beta) wave power as well as reduced mean frequencies which were present prior to treatment as well at the end of treatment. The EEG of patients exhibiting stable or improved scores on the Mini-Mental State examination (MMSE) at 12 weeks showed a significantly faster baseline mean alpha frequency as well as a significant reduction in relative circle minus power following the single THA test dose compared to deteriorated patients. A discriminant analysis using test dose response EEG variables correctly classified 75-79% of these two patients groups, suggesting that this procedure may be a useful approach for optimizing patients selection for antidementia treatments. (C) 2000 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:12:36