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Titolo:
Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain
Autore:
Nickola, TJ; Ignatowski, TA; Spengler, RN;
Indirizzi:
SUNY Buffalo, Sch Med & Biomed Sci, Dept Pathol, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 Sci, Dept Pathol, Buffalo, NY 14214 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1, volume: 107, anno: 2000,
pagine: 50 - 58
SICI:
0165-5728(20000710)107:1<50:ADAMTI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; CLONIDINE; RELEASE; RECEPTORS; ALPHA-2-ADRENOCEPTORS; DESIPRAMINE; INHIBITION; EXPRESSION; MODULATION; PAIN;
Keywords:
antidepressant drugs; alpha(2)-adrenergic receptor activation; tumor necrosis factor; pain; hippocampus; locus coeruleus; microinfusion; brain; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Spengler, RN SUNY Buffalo, Sch Med & Biomed Sci, Dept Pathol, 204 Farber Hall,3435 MainSt, Buffalo, NY 14214 USA SUNY Buffalo 204 Farber Hall,3435 Main St Buffalo NY USA 14214
Citazione:
T.J. Nickola et al., "Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain", J NEUROIMM, 107(1), 2000, pp. 50-58

Abstract

A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in responseto modifications in the other's effects. Changes in presynaptic adrenergicsensitivity as well as neuronal sensitivity to TNF have been implicated inthe mechanism of action of antidepressant drugs. The present study examines the influence of alpha(2)-adrenergic receptor activation on levels of TNFin regions of the brain associated with adrenergic function and the expression of mood. Additionally, the role of TNF as a neuromodulator is demonstrated by in vivo microinfusion of rrTNF proximal to the hippocampus. Administration to rats of an alpha(2)-adrenergic receptor agonist (clonidine) decreases levels of TNF in homogenates of rat locus coeruleus and hippocampus within 7.5 min. Chronic (14 days) administration of the antidepressant drugsdesipramine or zimelidine transforms alpha(2)-adrenergic receptor-dependent decreases in TNF levels to increases in levels of TNF in the locus coeruleus. This transformation to an increase in total levels of TNF also occurs,although transiently, in the hippocampus following acute (1 day) antidepressant drug administration. The effect of TNF on presynaptic alpha(2)-adrenergic sensitivity was also investigated. Field stimulation of hippocampal slices from rats microinfused with rrTNF proximal to the hippocampus for 14 days demonstrates a decrease in fractional release of [H-3]NE and an increase in alpha(2)-adrenergic autoreceptor sensitivity. These data demonstrate amutual dependence between alpha(2)-adrenergic receptor activation and levels of TNF in the central nervous system that would culminate in an increasein neurotransmitter release following antidepressant drug administration. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:32:41