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Titolo:
In activated mast cells, IL-1 up-regulates the production of several Th2-related cytokines including IL-9
Autore:
Hultner, L; Kolsch, S; Stassen, M; Kaspers, U; Kremer, JP; Mailhammer, R; Moeller, J; Broszeit, H; Schmitt, E;
Indirizzi:
GSF, Inst Expt Hamatol, Natl Res Ctr Environm & Hlth, D-81377 Munich, Germany GSF Munich Germany D-81377 Ctr Environm & Hlth, D-81377 Munich, Germany Univ Mainz, Inst Immunol, D-6500 Mainz, Germany Univ Mainz Mainz GermanyD-6500 inz, Inst Immunol, D-6500 Mainz, Germany Univ Munich, Med Klin Innenstadt, Div Clin Pharmacol, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 Clin Pharmacol, D-8000 Munich, Germany
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 11, volume: 164, anno: 2000,
pagine: 5556 - 5563
SICI:
0022-1767(20000601)164:11<5556:IAMCIU>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-ENHANCING ACTIVITY; CONNECTIVE-TISSUE-TYPE; CD4(+) T-CELLS; TRANSGENIC MICE; MESSENGER-RNA; BRONCHIAL HYPERRESPONSIVENESS; PROTECTIVE IMMUNITY; SCHISTOSOMA-MANSONI; TNF-ALPHA; C-KIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Hultner, L GSF, Inst Expt Hamatol, Natl Res Ctr Environm & Hlth, Marchioninistr 25, D-81377 Munich, Germany GSF Marchioninistr 25 Munich Germany D-81377 7 Munich, Germany
Citazione:
L. Hultner et al., "In activated mast cells, IL-1 up-regulates the production of several Th2-related cytokines including IL-9", J IMMUNOL, 164(11), 2000, pp. 5556-5563

Abstract

Mast cells can play detrimental roles in the pathophysiology and mortalityobserved in anaphylaxis and other Th2-dominated allergic diseases. In contrast, these cells contribute to protective host defense mechanisms against parasitic worm infections. After IgE/Ag activation, mast cells can produce multiple cytokines that may enhance allergic inflammations, while a similarpanel of Th2-related cytokines may support immunological strategies against parasites. Here we report that in primary mouse bone marrow-derived mast cells activated by ionomycin or IgE/Ag, the proinflammatory mediator IL-I (alpha or beta) up-regulated production of IL-3, IL-5. IL-6, and IL-9 as well as TNF, i.e., cytokines implicated in many inflammatory processes including those associated with allergies and helminthic infections. IL-1 did not induce significant cytokine release In the absence of ionomycin or IgE/Ag, suggesting that Ca-dependent signaling was required. IL-l-mediated enhancement of cytokine expression was confirmed at the mRNA level by Northern blotand/or RT-PCR analysis. Our study reveals a role for IL-I in the up-regulation of multiple mast cell-derived cytokines, Moreover, we identify mast cells as a novel source of IL-9, These results are of particular Importance in the light of recent reports that strongly support a central role of IL-9 in allergic lung inflammation and in host defense against worm infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:18:13