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Titolo:
Sex differences in the pharmacokinetics of dehydroepiandrosterone (DHEA) after single- and multiple-dose administration in healthy older adults
Autore:
Frye, RF; Kroboth, PD; Kroboth, FJ; Stone, RA; Folan, M; Salek, FS; Pollock, BG; Linares, AM; Hakala, C;
Indirizzi:
Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 eut Sci, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Med, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ept Med, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Biostat, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 sychiat, Pittsburgh, PA 15261 USA Belmar Pharm, Lakewood, CO USA Belmar Pharm Lakewood CO USABelmar Pharm, Lakewood, CO USA
Titolo Testata:
JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 6, volume: 40, anno: 2000,
pagine: 596 - 605
SICI:
0091-2700(200006)40:6<596:SDITPO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL DEHYDROEPIANDROSTERONE; SERUM LEVELS; POSTMENOPAUSAL WOMEN; INDIVIDUAL VARIATION; DOUBLE-BLIND; ELDERLY MEN; REPLACEMENT; SULFATE; AGE; SULFOTRANSFERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kroboth, PD Univ Pittsburgh, Dept Pharmaceut Sci, 904 Salk Hall,3501 Terrace St, Pittsburgh, PA 15261 USA Univ Pittsburgh 904 Salk Hall,3501 Terrace St Pittsburgh PA USA 15261
Citazione:
R.F. Frye et al., "Sex differences in the pharmacokinetics of dehydroepiandrosterone (DHEA) after single- and multiple-dose administration in healthy older adults", J CLIN PHAR, 40(6), 2000, pp. 596-605

Abstract

The pharmacokinetics of exogenously administered DHEA have not been well characterized despite its increasing use in therapeutic and research investigations. The purpose of this stud was to evaluate the pharmacokinetics of DHEA and its sulfated metabolite (DHEA-S) after single- and multiple-dose oral administration of DHEA 200 mg. Healthy older adult volunteers (7 women, 6 men) ages 65 to 79 years were studied on five visits separated by 1 week Subjects received daily administration of placebo (days 1 to 7), DHEA 200 mg (days 8 to 22), and placebo (days 23 to 29). Blood samples were collectedover 24 hours on days 1, 8, 15, 22, and 29 for DHEA and DHEA-S determinations by RIA. Pharmacokinetic parameter estimates were calculated by noncompartmental methods. Administration of DHEA 200 mg resulted in higher DHEA C-max, AUG, and overall concentrations in women than in men (p < 0.03); DHEA-Sparameter estimates were similar between men and women. Following a singledose of DHEA 200 mg, DHEA concentrations increased 5- to 6-fold in both men and women, and DHEA-S concentrations increased 5-fold in men and 21-fold in women relative to endogenous concentrations. The results of this study indicate th at the pharmacokinetics of DHEA differ between older men and women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:29:37