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Titolo:
Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique
Autore:
Browne, TR; Szabo, GK; Leppik, IE; Josephs, E; Paz, J; Baltes, E; Jensen, CM;
Indirizzi:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ, Sch Med, Dept Pharmacol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Med, Dept Pharmacol, Boston, MA 02118 USA Dept Vet Affairs Med Ctr, Neurol Serv, Boston, MA USA Dept Vet Affairs MedCtr Boston MA USA Ctr, Neurol Serv, Boston, MA USA MINCEP Epilepsy Care, Minneapolis, MN USA MINCEP Epilepsy Care Minneapolis MN USA ilepsy Care, Minneapolis, MN USA UCB Pharma Inc, Braine Alleud, Belgium UCB Pharma Inc Braine Alleud Belgium Pharma Inc, Braine Alleud, Belgium UCB Pharma Inc, Atlanta, GA USA UCB Pharma Inc Atlanta GA USAUCB Pharma Inc, Atlanta, GA USA
Titolo Testata:
JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 6, volume: 40, anno: 2000,
pagine: 590 - 595
SICI:
0091-2700(200006)40:6<590:AOPDIO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ULTRAVIOLET DETECTION; SERUM CONCENTRATION; STABLE ISOTOPES; CARBAMAZEPINE; BIOAVAILABILITY; ALTERNATIVES; QUANTITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Browne, TR VA Med Ctr, Neurol Serv, 150 S Huntington Ave, Boston, MA 02130USA VA Med Ctr 150 S Huntington Ave Boston MA USA 02130 A 02130 USA
Citazione:
T.R. Browne et al., "Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique", J CLIN PHAR, 40(6), 2000, pp. 590-595

Abstract

Levetimcetam has recently been approved as an adjunctive medication for partial seizures and frequently will be added to phenytoin. The objective of this study was to determine the presence or absence of a pharmacokinetic drug interaction of levetimcetam with phenytoin. A stable isotope tracer technique using deuterium-labeled (D-10) phenytoin and highperformance liquid chromatography with ultraviolet detection (rather than mass spectrometry detection) was employed, Tracer doses of D-10-phenptoin were administered IV before and 12 weeks after adding levetiracetam to the regimen of 6 subjects on phenytoin monotherapy for epilepsy. Blood was collected for 96 hours after each infusion. The following pharmacokinetic parameters were determined for phenytoin: C-max, C-min, C-ave, AUC, CL, t(1/2), VD, and free (nonprotein bound) fraction. The ra tio and the 90% confidence interval of the ratioof log-transformed mean values for phenytoin pharmacokinetic parameters before (denominator) and after (numerator) adding levetiracetam all fell within the range of 0.85 to 1.17 (two one-sided test). The authors conclude that the addition of levetiracetam did not bring about clinically important changes in phenytoin pharmacokinetic parameters and that it is not necessary to change the phenytoin dosing rate when levetiracetam is added to phenytoin.

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Documento generato il 23/01/20 alle ore 03:44:43