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Titolo:
Lysosome-endosome fusion and lysosome biogenesis
Autore:
Luzio, JP; Rous, BA; Bright, NA; Pryor, PR; Mullock, BM; Piper, RC;
Indirizzi:
Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Dept Clin Biochem, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY hem, Cambridge CB2 2XY, England Univ Cambridge, Addenbrookes Hosp, Wellcome Trust Ctr Study Mol MechanismsDis, Cambridge Inst Med Res, Cambridge CB2 2XY, England Univ Cambridge Cambridge England CB2 2XY Res, Cambridge CB2 2XY, England Univ Iowa, Dept Physiol & Biophys, Iowa City, IA 52242 USA Univ Iowa IowaCity IA USA 52242 ysiol & Biophys, Iowa City, IA 52242 USA
Titolo Testata:
JOURNAL OF CELL SCIENCE
fascicolo: 9, volume: 113, anno: 2000,
pagine: 1515 - 1524
SICI:
0021-9533(200005)113:9<1515:LFALB>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERMANSKY-PUDLAK-SYNDROME; TRANS-GOLGI NETWORK; 6-PHOSPHATE RECEPTOR TRAFFICKING; INTEGRAL MEMBRANE-PROTEINS; AP-3 ADAPTER COMPLEX; SACCHAROMYCES-CEREVISIAE; ENDOCYTIC PATHWAY; YEAST VACUOLE; MULTIVESICULAR ENDOSOMES; INTRACELLULAR-TRANSPORT;
Keywords:
lysosome; endosome; endocytosis; membrane fusion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
124
Recensione:
Indirizzi per estratti:
Indirizzo: Luzio, JP Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Dept Clin Biochem, Wellcome Trust MRC Bldg,Hills Rd, Cambridge CB2 2XY, England Univ Cambridge Wellcome Trust MRC Bldg,Hills Rd Cambridge England CB2 2XY
Citazione:
J.P. Luzio et al., "Lysosome-endosome fusion and lysosome biogenesis", J CELL SCI, 113(9), 2000, pp. 1515-1524

Abstract

Recent data both from cell-free experiments and from cultured cells have shown that lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fusewith late endosomes, a hybrid organelle for digestion of endocytosed macromolecules is created. Lysosomes are then re-formed from hybrid organelles by a process involving condensation of contents. In this Commentary we review the evidence for formation of the hybrid organelles and discuss the current status of our understanding of the mechanisms of fusion and lysosome re-formation. We also review lysosome biosynthesis, showing how recent studiesof lysosome-like organelles including the yeast vacuole, Drosophila eye pigment granules and mammalian secretory lysosomes have identified novel proteins involved in this process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 15:04:47