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Titolo:
Progenitor endothelial cells on vascular grafts: an ultrastructural study
Autore:
Maeda, M; Fukui, A; Nakamura, T; Inada, Y; Tamai, S; Haga, S; Tatsumi-Nagano, K; Yamamoto, H; Ogata, S; Iwata, H; Ikada, Y;
Indirizzi:
Nara Med Univ, Dept Anat, Kashihara, Nara 6348522, Japan Nara Med Univ Kashihara Nara Japan 6348522 Kashihara, Nara 6348522, Japan Nara Med Univ, Dept Orthoped Surg, Kashihara, Nara 6348522, Japan Nara MedUniv Kashihara Nara Japan 6348522 Kashihara, Nara 6348522, Japan Kyoto Univ, Inst Frontier Med Sci, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Inst Frontier Med Sci, Kyoto, Japan
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 1, volume: 51, anno: 2000,
pagine: 55 - 60
SICI:
0021-9304(200007)51:1<55:PECOVG>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY; HEMATOPOIETIC-CELLS; PTFE PROSTHESES; IDENTIFICATION; EXPRESSION; VASCULOGENESIS; ANGIOGENESIS; MECHANISMS; SURFACE; FAILURE;
Keywords:
PTFE; vascular graft; graft healing; CD34; Flk-1; progenitor endothelial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Maeda, M Nara Med Univ, Dept Anat, 840 Shijo Cho, Kashihara, Nara 6348522,Japan Nara Med Univ 840 Shijo Cho Kashihara Nara Japan 6348522 2, Japan
Citazione:
M. Maeda et al., "Progenitor endothelial cells on vascular grafts: an ultrastructural study", J BIOMED MR, 51(1), 2000, pp. 55-60

Abstract

The morphology of progenitor endothelial cells on vascular graft surfaces is addressed in this report. Such cells were seen to attach to intima-expressed CD34 and Flk-1 antigen and showed positive 5-bromo-2-deoxyuridine (BrdU) uptake. We examined CD34 and Flk-1 antigen-expressing endothelial progenitor cells three-dimensionally using confocal laser scanning microscopy (CLSM). Under detailed CLSM observation, through an ameboid-form cell, these progenitor endothelial cells changed from a globular to a flattened form. Wealso investigated these morphological changes using scanning electron microscopy. From these results, progenitor endothelial cells were observed not only near the advancing edge of endothelium, but also around the developingintimal site. Their form also changed from globular to flattened as observed in the CLSM results. These morphological changes were seen more frequently near the advancing edge and around the developing intimal site. They attached directly to vascular prosthesis fibers and likewise covered the graftluminal surface. Progenitor endothelial cells in any form had a common surface structure. We conclude from our results that progenitor endothelial cells can attach to graft fibers directly without clotting and directly coverthe graft luminal surfaces. (C) 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 51, 55-60, 2000.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 18:15:55