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Titolo:
Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15
Autore:
Bean, AJ; Davanger, S; Chou, MF; Gerhardt, B; Tsujimoto, S; Chang, YC;
Indirizzi:
Univ Texas, Sch Med, Dept Neurobiol & Anat, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 t Neurobiol & Anat, Houston, TX 77030 USA Univ Texas, Sch Med, WM Keck Ctr Neurobiol Learning & Memory, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Learning & Memory, Houston, TX 77030 USA Univ Bergen, Dept Cell Biol & Anat, N-5009 Bergen, Norway Univ Bergen Bergen Norway N-5009 Cell Biol & Anat, N-5009 Bergen, Norway
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 20, volume: 275, anno: 2000,
pagine: 15271 - 15278
SICI:
0021-9258(20000519)275:20<15271:HRREVI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE SUBSTRATE; ADRENAL CHROMAFFIN CELLS; GROWTH-FACTOR RECEPTOR; SYNAPTIC VESICLE ENDOCYTOSIS; PROTEIN-PROTEIN INTERACTIONS; EH-DOMAIN; MULTIVESICULAR ENDOSOMES; HIPPOCAMPAL SYNAPSES; ACTIVE ZONE; CLATHRIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bean, AJ Univ Texas, Sch Med, Dept Neurobiol & Anat, 6431 Fannin St,Rm 7-208, Houston, TX 77030 USA Univ Texas 6431 Fannin St,Rm 7-208 Houston TX USA77030 77030 USA
Citazione:
A.J. Bean et al., "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15", J BIOL CHEM, 275(20), 2000, pp. 15271-15278

Abstract

Hrs-a, via interactions with SNAP-25, plays a regulatory role on the exocytic machinery. We now show that Hrs-a physically interacts with Eps15, a protein required for receptor-mediated endocytosis. The Hrs-2/Eps15 interaction is calcium dependent, inhibited by SNAP-25 and alpha-adaptin, and results in the inhibition of receptor-mediated endocytosis. Immunoelectron microscopy reveals Hrs-2 localization on the limiting membrane of multivesicular bodies, organelles in the endosomal pathway. These data show that Hrs-8 regulates endocytosis, delineate a biochemical pathway (Hrs-2-Eps15-AP2) in which Hrs-a functions, and suggest that Hrs-a acts to provide communication between endo- and exocytic processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:37:51