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Titolo:
A mammalian iron ATPase induced by iron
Autore:
Baranano, DE; Wolosker, H; Bae, BI; Barrow, RK; Snyder, SH; Ferris, CD;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 av Sci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 nterol, Baltimore, MD 21205 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 20, volume: 275, anno: 2000,
pagine: 15166 - 15173
SICI:
0021-9258(20000519)275:20<15166:AMIAIB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; OXIDATIVE STRESS; HEME OXYGENASE; RESPONSIVE ELEMENT; CELLULAR IRON; MENKES GENE; RAT-LIVER; TRANSPORT; METABOLISM; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ferris, CD Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 timore, MD 21205 USA
Citazione:
D.E. Baranano et al., "A mammalian iron ATPase induced by iron", J BIOL CHEM, 275(20), 2000, pp. 15166-15173

Abstract

While molecular mechanisms for iron entry and storage within cells have been elucidated, no system to mediate iron efflux has been heretofore identified. We now describe an ATP requiring iron transporter in mammalian cells. Fe-55 is transported into microsomal vesicles in a Mg-ATP-dependent fashion. The transporter is specific for ferrous iron, is temperature- and time-dependent, and detected only with hydrolyzable nucleotides. It differs from all known ATPases and appears to be a P-ty-pe ATPase. The Fe-ATPase is localized together with heme ogygenase-1 to microsomal membranes with both proteins greatly enriched in the spleen. Iron treatment markedly induces ATP-dependent iron transport in RAW 264.7 macrophage cells with an initial phase that is resistant to cycloheximide and actinomycin D and a later phase that is inhibited by these agents. Iron release, elicited in intact rats by glycerol-induced rhabdomyolysis, induces ATP-dependent iron transport in the kidney. Mice with genomic deletion of heme oxygenase-l have selective tissue iron accumulation and display augmented ATP-dependent iron transport in those tissues that accumulate iron.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:28:19