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Titolo:
The potential role of natural tumor promoters in marine turtle fibropapillomatosis
Autore:
Landsberg, JH; Balazs, GH; Steidinger, KA; Baden, DG; Work, TM; Russell, DJ;
Indirizzi:
Florida Marine Res Inst, Florida Fish & Wildlife Conservat Commiss, St Petersburg, FL 33701 USA Florida Marine Res Inst St Petersburg FL USA 33701 tersburg, FL 33701 USA Natl Marine Fisheries Serv, Honolulu Lab, SW Fisheries Sci Ctr, Honolulu, HI 96822 USA Natl Marine Fisheries Serv Honolulu HI USA 96822 , Honolulu, HI 96822 USA Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Marine & Freshwater Biomed Sci Ctr, Natl Inst Environm Hlth Sci, Miami, FL 33149 USA Univ Miami Miami FL USA 33149 Inst Environm Hlth Sci, Miami, FL 33149 USA US Geol Survey, Biol Resources Div, Natl Wildlife Hlth Ctr, Honolulu FieldStn, Honolulu, HI 96850 USA US Geol Survey Honolulu HI USA 96850 ulu FieldStn, Honolulu, HI 96850 USA Univ Alaska SE, Dept Biol, Juneau, AK 99801 USA Univ Alaska SE Juneau AK USA 99801 ka SE, Dept Biol, Juneau, AK 99801 USA
Titolo Testata:
JOURNAL OF AQUATIC ANIMAL HEALTH
fascicolo: 3, volume: 11, anno: 1999,
pagine: 199 - 210
SICI:
0899-7659(199909)11:3<199:TPRONT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
OKADAIC ACID CLASS; PROTEIN PHOSPHATASE INHIBITOR; CHELONIA-MYDAS L; GREEN TURTLE; HAWAIIAN-ISLANDS; CALYCULIN-A; MOUSE SKIN; CELL-TRANSFORMATION; CHEMICAL COFACTORS; PROROCENTRUM-LIMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Landsberg, JH Florida Marine Res Inst, Florida Fish & Wildlife Conservat Commiss, 100 8th Ave SE, St Petersburg, FL 33701 USA Florida Marine Res Inst100 8th Ave SE St Petersburg FL USA 33701
Citazione:
J.H. Landsberg et al., "The potential role of natural tumor promoters in marine turtle fibropapillomatosis", J AQUAT A H, 11(3), 1999, pp. 199-210

Abstract

Fibropapillomatosis (FP) in green turtles Chelonia mydas is a debilitating, neoplastic disease that has reached worldwide epizootic levels. The etiology of FP is unknown but has been linked to oncogenic viruses. Toxic benthic dinoflagellates (Prorocentrum spp.) are not typically considered tumorigenic agents, yet they have a worldwide distribution and produce a tumor promoter, okadaic acid (OA). Prorocentrum spp. are epiphytic on macroalgae and seagrasses that are normal components of green turtle diets. Here we show that green turtles in the Hawaiian Islands consume Prorocentrum and that high-risk FP areas are associated with areas where P. lima and P. concavum areboth highly prevalent and abundant. The presence of presumptive OA in the tissues of Hawaiian green turtles further suggests exposure and a potentialrole for this tumor promoter in the etiology of FP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 13:53:40