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Titolo:
Children at risk for asthma: Home allergen levels, lymphocyte proliferation, and wheeze
Autore:
Finn, PW; Boudreau, JO; He, HZ; Wang, YS; Chapman, MD; Vincent, C; Burge, HA; Weiss, ST; Perkins, DL; Gold, DR;
Indirizzi:
Brigham & Womens Hosp, Div Resp & Crit Care, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Crit Care, Boston, MA 02115 USA Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Div Renal, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 nning Lab, Boston, MA 02115 USA Beth Israel Hosp, Div Pulm, Boston, MA 02215 USA Beth Israel Hosp Boston MA USA 02215 Hosp, Div Pulm, Boston, MA 02215 USA Univ Virginia, Asthma & Allerg Dis Ctr, Charlottesville, VA USA Univ Virginia Charlottesville VA USA rg Dis Ctr, Charlottesville, VA USA
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 5, volume: 105, anno: 2000,
pagine: 933 - 942
SICI:
0091-6749(200005)105:5<933:CARFAH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVIRONMENTAL ENDOTOXIN MEASUREMENT; LOWER RESPIRATORY ILLNESS; HOUSE-DUST MITES; T-CELL MEMORY; EARLY-CHILDHOOD; INHALANT ALLERGENS; NATURAL-HISTORY; LIMULUS ASSAY; EXPOSURE; CAT;
Keywords:
children; T lymphocytes; proliferation; home allergen levels; allergy; asthma; cockroach; Bla g 2; Der f 1; Fel d 1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Finn, PW Brigham & Womens Hosp, Div Resp & Crit Care, 75 Francis St, Boston, MA 02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA 02115 02115 USA
Citazione:
P.W. Finn et al., "Children at risk for asthma: Home allergen levels, lymphocyte proliferation, and wheeze", J ALLERG CL, 105(5), 2000, pp. 933-942

Abstract

Background: Allergic asthma is a common childhood disease. Although T-lymphocyte activation plays a critical role in allergic asthma, the environmental factors promoting lymphocyte activation in children are not well defined. Objective: In a cohort of children at risk for asthma (n = 114), we determined whether the levels of cockroach (Bla g 1 or 2), house dust mite (Der f1), and cat allergen (Fel d 1) in the home during infancy mas associated with subsequent allergen-specific lymphocyte proliferation in later life. Methods: Dust samples from multiple sites in the home were collected at 3 months of age and were measured for allergen levels. Serial questionnaires were applied. At a median age of 2 years, PBMCs were isolated and lymphocyte proliferation to the home allergens and PHA was determined. Results: Increased lymphocyte proliferative responses to Bla g 2 were associated with higher home levels of Bla g 1 or 2 (P for trend with kitchen Bla g levels = .011), in analyses adjusting for cold in the past week. Proliferative responses to Der fl were higher in homes with family room levels ofDer f 1 greater than or equal to 10 mu g/g dust than in homes with Der f 1<2 mu g/g, but differences were not significant in analyses adjusting for cold (P = .15). Repeated wheeze in the first 2 years of life was associatedwith increased allergen-specific and PHA proliferative responses. Conclusion: Early-life cockroach allergen exposure at 3 months of age predicts allergen-specific lymphocyte proliferative responses at a median of 2 years of age.

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Documento generato il 01/12/20 alle ore 00:34:45